gene 2,230 words KG: MYOT 2026-03-26
kind:genesection:genesstate:publishedtopic:neuromusculartopic:myopathytopic:protein-aggregation
Contents

MYOT Gene

🧬 Gene Info
Gene SymbolMYOT
Chromosome19q13.33
Functionis a gene encoding a Z-disc protein critical for sarcomere organization and maintenance.
Molecular Weight57 kDa
Amino Acids493 aa
Exons13
Pathwaysubiquitin-proteasome
Ensembl IDENSG00000136244
GeneCardsMYOT
Human Protein AtlasMYOT
Associated DiseasesMyofibrillar Myopathy
InteractionsNBR1, P62, BRCA1, DES, DNAJB6, FLNC
KG Connections150 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Multi-Modal Stress Response Harmonization
Score: 0.60

Related Analyses (28)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: co_discussed
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
FLNC Gene
gene · KG edge: activates
DNAJB6 Gene
gene · KG edge: activates
DES Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

MYOT degrades NBR1
MYOT degrades P62
MYOT degrades SQSTM1
MYOT causes myofibrillar myopathy
MYOT causes Myofibrillar Myopathy
MYOT activates NBR1
MYOT activates P62
MYOT associated_with P62
MYOT associated_with DES
MYOT associated_with BRCA1