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gene 2,230 words KG: MYOT
Contents

MYOT Gene

🧬 Gene Info
Gene SymbolMYOT
Chromosome19q13.33
Functionis a gene encoding a Z-disc protein critical for sarcomere organization and maintenance.
Molecular Weight57 kDa
Amino Acids493 aa
Exons13
Pathwaysubiquitin-proteasome
Ensembl IDENSG00000136244
GeneCardsMYOT
Human Protein AtlasMYOT
Associated Diseasesmyofibrillar myopathy
InteractionsAUTOPHAGY, BRCA1, DES, DNAJB6, FLNC, GENES
KG Connections149 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (93)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Transcriptional Autophagy-Lysosome Coupling
Score: 0.78Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77CYP46A1 Overexpression Gene Therapy
Score: 0.77Circadian Clock-Autophagy Synchronization
Score: 0.76Multi-Modal Stress Response Harmonization
Score: 0.76Circadian-Synchronized Proteostasis Enhancement
Score: 0.74Smartphone-Detected Motor Variability Correction
Score: 0.74Senescent Cell Mitochondrial DNA Release
Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Epigenetic Memory Erasure via TET2 Activation
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Phase-Separated Organelle Targeting
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
pg 1/5Next →

Related Analyses (27)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: co_discussedAMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussedAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activatesGenes
index · KG edge: activatesABCD3 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

MYOT causes myofibrillar myopathy
MYOT causes Myofibrillar Myopathy
BRCA1 degrades MYOT
DES degrades MYOT
DNAJB6 degrades MYOT
FLNC degrades MYOT
MYOT degrades NBR1
MYOT degrades P62
MYOT degrades SQSTM1
BRCA1 activates MYOT

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