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Home / Wiki / Entity: SQSTM1/p62

entity 1,760 words KG: SQSTM1/p62 2026-03-23

kind:entity section:entities state:published

Contents

SQSTM1/p62

Knowledge Graph

Related Hypotheses (17)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66 Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53 Cell-Type Specific TFEB Modulation
Score: 0.48 VCP-Mediated Autophagy Enhancement
Score: 0.41 Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat
Score: 0.52

APOE-Dependent Autophagy Restoration
Score: 0.61 Multi-Modal Stress Response Harmonization
Score: 0.60 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57 Phase-Separated Organelle Targeting
Score: 0.52 Stress Granule Phase Separation Modulators
Score: 0.49 Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48 RNA Granule Nucleation Site Modulation
Score: 0.48 Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44 Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43 Glycine-Rich Domain Competitive Inhibition
Score: 0.43 The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40

Related Analyses (10)

What determines the spatial organization of autophagy recept
neurodegeneration · failed TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (16)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90 Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90 P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90 iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85 Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40 ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40 Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40 Gene expression analysis of autophagy targets following treh
exploratory · proposed · Score: 0.85 Trehalose-induced autophagy gene expression analysis
exploratory · proposed · Score: 0.85 Acteoside treatment in LPS-induced SALI mouse model
validation · proposed · Score: 0.90 Nrf2 inhibitor ML385 mechanism validation experiment
exploratory · proposed · Score: 0.85 Acteoside effects on RAW264.7 macrophage cells
exploratory · proposed · Score: 0.85 TRIM21-mediated K63-linked ubiquitination of G3BP1
exploratory · proposed · Score: 0.95 G3BP1-mediated stress granule assembly via liquid-liquid pha
exploratory · proposed · Score: 0.90 Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic
validation · proposed · Score: 0.40

See Also (1)

MAPK/ERK Signaling Pathway in Neurodegeneration
mechanism · KG edge: inhibits

Knowledge Graph (2 edges)

SQSTM1/p62 interacts_with G3BP1

SQSTM1/p62 inhibits MAPK/ERK

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