mechanism 991 words KG: MAPK/ERK 2026-04-01
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

MAPK/ERK Signaling Pathway in Neurodegeneration

Mechanism Info
NameMAPK/ERK
SummaryThe role of mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) signaling in Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders
Key Genes/ProteinsTARDBP, NPY, EGR1, SQSTM1/p62, integrins, Trk-B
Related Diseasesreduced loading
Related Pathwaysautophagy

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Can biased TREM2 agonists selectively activate DAP12-SYK-PI3
molecular biology · failed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (12 edges)

MAPK/ERK promotes neurodegeneration
MAPK/ERK phosphorylates TARDBP
MAPK/ERK activates Trk-B
MAPK/ERK activates EGR1
integrins activates MAPK/ERK
reduced loading inhibits MAPK/ERK
ERK activates MAPK/ERK
MAPK activates MAPK/ERK
AUTOPHAGY activates MAPK/ERK
AKT inhibits MAPK/ERK