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disease 6,462 words KG: FTD
Contents

Frontotemporal Dementia (FTD)

Disease Info
Behavioral variant FTD (bvFTD)Progressive changes in personality, social conduct, and executive function, with early behavioral disinhibition, apathy, loss of empathy, and compulsive/ritualistic behaviors
Associated GenesACHE, AD, AKT, AMYLOID, APOE, APP, BDNF, C9orf72
KG Connections792 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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OMIMMeSHWikipedia

Related Hypotheses (23)

TDP-43 RNA-proteostasis failure across ALS, FTD, and AD/LATE
Score: 0.83Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.82C9ORF72 autophagy-lysosome collapse across ALS and FTD
Score: 0.82MAPT tau seeding and release across AD, FTD, and PD-spectrum
Score: 0.81Stress-granule RNA-binding protein phase transition across A
Score: 0.78TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, a
Score: 0.78ASO-mediated reduction of toxic C9orf72 dipeptide repeat pro
Score: 0.76GRN/progranulin lysosomal insufficiency across FTD, ALS-spec
Score: 0.76C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD
Score: 0.72C9orf72 repeat RNA and dipeptide-repeat toxicity in ALS/FTD
Score: 0.70Astrocyte-Neuron Metabolic Coupling Failure Precedes Neurode
Score: 0.69TDP-43 phase-separation and nuclear-function failure in ALS/
Score: 0.69FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensa
Score: 0.68Stathmin-2 Splice Switching to Prevent Axonal Degeneration A
Score: 0.66ATXN2 Antisense Oligonucleotides Reduce Dipeptide Repeat Pro
Score: 0.63Nrf2 Pathway Activation Compensates for Progranulin Haploins
Score: 0.63Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulat
Score: 0.62TDP-43 LLPS and proteostasis dysregulation in ALS/FTD
Score: 0.60C9orf72 Nucleocytoplasmic Transport Rescue for ALS/FTD
Score: 0.60Small-Molecule Modulation of TDP-43 Liquid-Liquid Phase Sepa
Score: 0.56
pg 1/2Next →

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (9)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40Frontal and Temporal Lobe Selective Vulnerability in FTD — M
validation · proposed · Score: 0.40FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40

Knowledge Graph (12 edges)

TAU associated_with FTD
TAU causes FTD
FTD inhibits MITOCHONDRIAL_PROTEINS
FTD inhibits BIOENERGETICS
FTD regulates TAU
TDP43 associated_with FTD
C9ORF72 causes FTD
VESICLE_TRAFFICKING associated_with FTD
GGGGCC_repeat causes FTD
FTD regulates MITOCHONDRIAL_PROTEINS

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