concept

ACHE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACHE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

696Connections
0Hypotheses
25Analyses
50Outgoing
50Incoming

Summary

ACHE is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 279 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameACHE
Key Genes/ProteinsNORAD
Related DiseasesAls, denervation, Neurodegeneration
Related PathwaysApoptosis

Wiki Pages (20)

Knowledge base pages for this entity

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

CBS/PSP Treatment Rankings

therapeutic · 5434 words

Neuroprotection Strategies in Neurodegeneration

therapeutic · 4093 words

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

clinical · 3985 words

Astrocytes

cell · 3974 words

Pathway Diagram

graph TD
    ACHE["ACHE"]
    ACHE -->|"activates"| Alzheimer["Alzheimer"]
    ACHE -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ACHE -->|"activates"| Als["Als"]
    ACHE -->|"activates"| Inflammation["Inflammation"]
    ACHE -->|"activates"| Ms["Ms"]
    ACHE -->|"activates"| Anxiety["Anxiety"]
    ACHE -->|"target for"| Cardiac["Cardiac"]
    BPMC["BPMC"] -->|"inhibits"| ACHE
    MBP["MBP"] -->|"activates"| ACHE
    GENES["GENES"] -->|"activates"| ACHE
    MANF["MANF"] -->|"activates"| ACHE
    FLAVONOIDS["FLAVONOIDS"] -.biomarker for.-> ACHE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| ACHE
    PI3K["PI3K"] -->|"activates"| ACHE
    AKT["AKT"] -->|"activates"| ACHE
    TNF["TNF"] -.biomarker for.-> ACHE
    CAT["CAT"] -.biomarker for.-> ACHE

Outgoing (519)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
ds-6784494f1741provides_data_fordataset1.00
Alsinhibitsdisease0.85
denervationpromotesphenotype0.85
Acetylcholinedegradescompound0.82

Incoming (177)

SourceRelationTypeStr
ds-6784494f1741data_indataset1.00
ds-83b31ef18d49data_indataset1.00
Bpmcdownregulatescompound0.90
Bpmcinhibitscompound0.90
Fisetindownregulatescompound0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (25)

Scientific analyses that reference this entity

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

How can functional hyperconnectivity patterns distinguish compensatory mechanism

neurodegeneration | 2026-04-13 | 0 hypotheses

How can circuit-level neurodegeneration mechanisms be identified without complet

research methodology | 2026-04-11 | 0 hypotheses

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found