Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ACHE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ACHE is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 279 entities in the SciDEX knowledge graph.
| Name | ACHE |
| Key Genes/Proteins | NORAD |
| Related Diseases | Als, denervation, Neurodegeneration |
| Related Pathways | Apoptosis |
Knowledge base pages for this entity
graph TD
ACHE["ACHE"]
ACHE -->|"activates"| Alzheimer["Alzheimer"]
ACHE -->|"activates"| Neurodegeneration["Neurodegeneration"]
ACHE -->|"activates"| Als["Als"]
ACHE -->|"activates"| Inflammation["Inflammation"]
ACHE -->|"activates"| Ms["Ms"]
ACHE -->|"activates"| Anxiety["Anxiety"]
ACHE -->|"target for"| Cardiac["Cardiac"]
BPMC["BPMC"] -->|"inhibits"| ACHE
MBP["MBP"] -->|"activates"| ACHE
GENES["GENES"] -->|"activates"| ACHE
MANF["MANF"] -->|"activates"| ACHE
FLAVONOIDS["FLAVONOIDS"] -.biomarker for.-> ACHE
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| ACHE
PI3K["PI3K"] -->|"activates"| ACHE
AKT["AKT"] -->|"activates"| ACHE
TNF["TNF"] -.biomarker for.-> ACHE
CAT["CAT"] -.biomarker for.-> ACHE| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| ds-6784494f1741 | provides_data_for | dataset | 1.00 |
| Als | inhibits | disease | 0.85 |
| denervation | promotes | phenotype | 0.85 |
| Acetylcholine | degrades | compound | 0.82 |
| Apoptosis | activates | pathway | 0.80 |
| Neurodegeneration | activates | disease | 0.75 |
| Als | activates | disease | 0.75 |
| Oxidative Stress | activates | pathway | 0.70 |
| amyloidosis | associated_with | process | 0.70 |
| CHAT | associated_with | gene | 0.70 |
| Alzheimer | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Cardiac | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Neuroblastoma | causes | disease | 0.65 |
| Alzheimer | causes | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Inflammation | causes | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Diabetes | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Obesity | inhibits | disease | 0.65 |
| Type 2 Diabetes | inhibits | disease | 0.65 |
| CJD | treats | disease | 0.65 |
| CANCER | inhibits | disease | 0.65 |
| CANCER | regulates | disease | 0.65 |
| CANCER | treats | disease | 0.65 |
| CANCER | targets | disease | 0.65 |
| STING | causes | gene | 0.65 |
| DEMENTIA | targets | disease | 0.65 |
| BCL2 | targets | gene | 0.65 |
| STING | targets | gene | 0.65 |
| ISCHEMIA | contributes_to | disease | 0.65 |
| DIABETES | protects_against | disease | 0.65 |
| MULTIPLE SCLEROSIS | reduces | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-6784494f1741 | data_in | dataset | 1.00 |
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| Bpmc | downregulates | compound | 0.90 |
| Bpmc | inhibits | compound | 0.90 |
| Fisetin | downregulates | compound | 0.85 |
| Chlorogenic acid | downregulates | compound | 0.85 |
| NORAD | regulates | gene | 0.80 |
| APOPTOSIS | activates | gene | 0.80 |
| BPMC | inhibits | drug | 0.72 |
| OXIDATIVE STRESS | activates | gene | 0.70 |
| NEUROTOXICITY | activates | gene | 0.70 |
| GFAP | activates | gene | 0.70 |
| APP | causes | gene | 0.65 |
| MBP | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| MANF | activates | gene | 0.60 |
| MAF | associated_with | gene | 0.60 |
| MC4R | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| FLAVONOIDS | biomarker_for | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| CAT | biomarker_for | gene | 0.60 |
| KCNH2 | therapeutic_target | gene | 0.60 |
| IDH1 | therapeutic_target | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| SCN5A | therapeutic_target | gene | 0.60 |
| IL1B | therapeutic_target | gene | 0.60 |
| KCNQ1 | therapeutic_target | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| CALM1 | therapeutic_target | gene | 0.60 |
| LMNA | therapeutic_target | gene | 0.60 |
| LRP1 | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| PRESENILIN | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| AXON | activates | gene | 0.60 |
| TUBULIN | activates | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
| GADD45A | activates | gene | 0.60 |
| GFAP | inhibits | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.60 |
| MYELIN | activates | gene | 0.60 |
| ELAVL3 | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444
neurodegeneration | 2026-04-13 | 0 hypotheses
research methodology | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||