concept

ACHE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACHE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1070Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ACHE is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 279 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACHE
Key Genes/Proteins	AB, ABCA1, ACETYL-COA, ACHE, AD, ADAM10
Related Diseases	acetylcholine, Aging, Als
Related Pathways	Akt

Pathway Diagram

graph TD
    ACHE["ACHE"]
    ACHE -->|"activates"| Alzheimer["Alzheimer"]
    ACHE -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ACHE -->|"activates"| Als["Als"]
    ACHE -->|"activates"| Inflammation["Inflammation"]
    ACHE -->|"activates"| Ms["Ms"]
    ACHE -->|"activates"| Anxiety["Anxiety"]
    ACHE -->|"target for"| Cardiac["Cardiac"]
    BPMC["BPMC"] -->|"inhibits"| ACHE
    MBP["MBP"] -->|"activates"| ACHE
    GENES["GENES"] -->|"activates"| ACHE
    MANF["MANF"] -->|"activates"| ACHE
    FLAVONOIDS["FLAVONOIDS"] -.biomarker for.-> ACHE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| ACHE
    PI3K["PI3K"] -->|"activates"| ACHE
    AKT["AKT"] -->|"activates"| ACHE
    TNF["TNF"] -.biomarker for.-> ACHE
    CAT["CAT"] -.biomarker for.-> ACHE

Outgoing (891)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ACHE	encodes	protein	0.00
ds-6784494f1741	data_in	dataset	1.00
ds-6784494f1741	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
denervation	promotes	phenotype	0.85
Als	inhibits	disease	0.85
Acetylcholine	degrades	compound	0.82
Apoptosis	activates	pathway	0.80
Als	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
FOXP3	activates	gene	0.70
OPTN	activates	gene	0.70
NLRP3	activates	gene	0.70
CCL2	activates	gene	0.70
MULTIPLE SCLEROSIS	inhibits	disease	0.70
PYCARD	activates	gene	0.70
VEGF	associated_with	gene	0.70
OCLN	markers	gene	0.70
SQSTM1	activates	gene	0.70
LRRK2	inhibits	gene	0.70
SIRT1	activates	gene	0.70
ASTROCYTE	activates	cell_type	0.70
TAU	markers	gene	0.70
CCL2	inhibits	gene	0.70
CXCL10	inhibits	gene	0.70
STING	activates	gene	0.70
CGAS	activates	gene	0.70
GSK3B	activates	gene	0.70
LRRK2	activates	gene	0.70
HTR2A	regulates	gene	0.70
OLIGODENDROCYTE	activates	cell_type	0.70
TFEB	activates	gene	0.70
BDNF	biomarker_for	gene	0.70
CHRNA7	targets	gene	0.70
PARP1	inhibits	gene	0.70
TREM2	expressed_in	gene	0.70
APP	biomarker_for	gene	0.70
BIN1	markers	gene	0.70
GABAERGIC	regulates	cell_type	0.70
SLC6A4	targets	gene	0.70
ULK1	activates	gene	0.70
APOE	biomarker_for	gene	0.70
RAGE	activates	gene	0.70
BECN1	activates	gene	0.70
LAMP1	activates	gene	0.70
DOPAMINERGIC	regulates	cell_type	0.70
NEURONS	expresses	cell_type	0.70
STING	markers	gene	0.70
TNF	activates	gene	0.70

Incoming (179)

Source	Relation	Type	Str
ACHE	encodes	gene	0.00
H6	donepezil_target	hypothesis	0.00
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-6784494f1741	data_in	dataset	1.00
Bpmc	inhibits	compound	0.90
Bpmc	downregulates	compound	0.90
Fisetin	downregulates	compound	0.85
Chlorogenic acid	downregulates	compound	0.85
NORAD	regulates	gene	0.80
APOPTOSIS	activates	gene	0.80
BPMC	inhibits	drug	0.72
NEUROTOXICITY	activates	gene	0.70
GFAP	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
melatonin	modulates	drug	0.70
APP	causes	gene	0.65
AKT	activates	gene	0.60
SCN5A	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
PI3K	activates	gene	0.60
GENES	associated_with	gene	0.60
IDH1	therapeutic_target	gene	0.60
PRESENILIN	activates	gene	0.60
AMPK	activates	gene	0.60
KCNH2	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
BACE1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TUBULIN	activates	gene	0.60
NEURON	activates	gene	0.60
GADD45A	activates	gene	0.60
TAU	activates	gene	0.60
GAIN	activates	gene	0.60
LMNA	therapeutic_target	gene	0.60
CAT	biomarker_for	gene	0.60
BDNF	causes	gene	0.60
TAU	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
AMYLOID	causes	gene	0.60
ACETYL-COA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
ROS	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.735

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning ACHE in their description or question text

No additional research found