gene 1,915 words KG: ADRA2B 2026-03-22
kind:genesection:genesstate:published
Contents

adra2b Gene

🧬 Gene Info
Gene SymbolADRA2B
Full NameAlpha-2B Adrenergic Receptor
Chromosome2q24.1
Protein FamilyAdrenergic receptor family (GPCR)
Primary Expressionboth the central and peripheral nervous systems, where it regulates norepinephrine release, blood pressure, and various autonomic functions
Molecular Weight60 kDa
Amino Acids450 aa
PathwaysPI3-K, Wnt
UniProt IDP17787
NCBI Gene ID151
Ensembl IDENSG00000159692
GeneCardsADRA2B
Human Protein AtlasADRA2B
Protein ClassG protein-coupled receptor (Class A)
Brain ExpressionBrainstem, Cortex, Hippocampus, Hypothalamus
Associated Diseasesneurodegeneration
InteractionsIL13, WNT11, TNFRSF1B, TNFRSF13C, MYO7A, WNT1
KG Connections77 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Noradrenergic-Tau Propagation Blockade
Score: 0.51
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.42
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Multi-Modal Stress Response Harmonization
Score: 0.60
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
CHRNE Gene
gene · KG edge: expressed_in
ADRA2A Gene
gene · KG edge: expressed_in
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

ADRA2B provides_data_for ds-83b31ef18d49
ADRA2B activates NF-kappaB
ADRA2B upregulates p21(waf-1)
ADRA2B activates PI3-K
ADRA2B binds Rab8
ADRA2B binds GGA3
ADRA2B regulates cell surface expression
ADRA2B regulates ERK1/2 activation
ADRA2B regulates cAMP inhibition
ADRA2B exacerbates air pollution-induced behavior changes