biomarker 1,507 words KG: GABA 2026-03-24
kind:biomarkersection:biomarkersstate:publisheddisease:alzheimersdisease:parkinsons
Contents

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Disease Biomarker

🔬 Protein Info
Gene SymbolGABA
Chromosome12p12.3
Functionis a hallmark of neurodegeneration.
Primary Expressionhippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids602 aa
Exons14
PathwaysGABAergic Signaling
GeneCardsGABA
Human Protein AtlasGABA
GABA_A receptorsLigand-gated chloride channels mediating fast inhibitory signaling
GABA_B receptorsG-protein coupled receptors mediating slow, prolonged inhibition
Associated DiseasesALS, ALZHEIMER'S DISEASE, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsATG, MTOR, RB1CC1, JNK, MAVS, HUNTINGTON
KG Connections1323 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Heterogeneous astrocyte activation states differentially imp
Score: 0.52
Astrocyte-Mediated Microglial Memory Erasure
Score: 0.46
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65

Related Analyses (30)

Metabolomic signatures of neurodegeneration and energy metab
neurodegeneration · failed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (19)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
AMBRA1 Gene
gene · KG edge: associated_with
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: activates
AKT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

GABA co_discussed JNK
GABA co_discussed LC3
GABA co_discussed LRRK2
GABA co_discussed MTOR
GABA co_discussed ULK1
GABA co_discussed HISTONE
GABA co_discussed ISCHEMIA
GABA co_discussed HTT
GABA co_discussed MITOCHONDRIA
GABA co_discussed MITOPHAGY