| Gene Symbol | DHODH |
| Full Name | Dihydroorotate Dehydrogenase |
| Chromosome | 16q22.2 |
| Protein Type | Enzyme |
| Function | encodes a mitochondrial inner membrane enzyme that catalyzes the fourth step in de novo pyrimidine biosynthesis — the oxidation of dihydroorotate to orotate. |
| Primary Expression | Ubiquitous (mitochondrial inner membrane); enriched in metabolically active neurons |
| Molecular Weight | 43 kDa |
| Amino Acids | 395 aa |
| Exons | 10 |
| Pathways | Ferroptosis |
| UniProt ID | Q02127 |
| NCBI Gene ID | 1723 |
| Ensembl ID | ENSG00000102967 |
| OMIM | 126064 |
| GeneCards | DHODH |
| Human Protein Atlas | DHODH |
| Associated Diseases | ALS |
| Interactions | GCH1, FSP1, LONP1, ATF3, GPX4, NRF2 |
| KG Connections | 66 knowledge graph edges |
| Databases | GeneCardsHPASTRING |