gene 1,699 words KG: FTH1 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:nbia
Contents

FTH1 Gene — Ferritin Heavy Chain 1

🧬 Gene Info
Gene SymbolFTH1
Full NameFerritin Heavy Chain 1
Chromosome19q13.33
Protein FamilyFerritin heavy chain subunit
Functionis a hallmark of multiple neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS)[@ward2014].
Molecular Weight21 kDa
Exons4
PathwaysApoptosis, Blood-Brain Barrier, Ferroptosis, Metastasis, Mitophagy
UniProt IDP02794
NCBI Gene ID2495
Ensembl IDENSG00000196950
OMIM134790
GeneCardsFTH1
Human Protein AtlasFTH1
Ferroxidase centerLocated in FTH1, catalyzes Fe²⁺ → Fe³⁺ oxidation
Associated DiseasesALS, Carcinoma, Hepatocellular Carcinoma, Parkinson's disease, Tumor, stroke
Known Drugs/Compoundsparicalcitol, dimethyl malonate
InteractionsGPX4, SIRT1, BECLIN1, NCOA4, UBE2N, TAK1
KG Connections324 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Blood-Brain Barrier SPM Shuttle System
Score: 0.55

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (3)

Gandouling protection against brain injury in Wilson's disea
validation · proposed · Score: 0.90
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
CD44 - Cell Surface Glycoprotein
gene · KG edge: activates
BECN1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FTH1 inhibits GPX4
FTH1 associated_with P62
FTH1 associated_with MAP1LC3A
FTH1 associated_with PTGS2
FTH1 associated_with NCOA4
FTH1 associated_with TP53
FTH1 associated_with BECN1
FTH1 associated_with MAP1LC3B
FTH1 associated_with TGFB1
FTH1 associated_with ACTB