gene 1,645 words KG: EGLN1
Contents

EGLN1 — Egl-9 Family Prolyl Hydroxylase 1

🧬 Gene Info
Gene SymbolEGLN1
Full NameEgl-9 Family Prolyl Hydroxylase 1
Chromosome1q42.12
Protein TypeTranscription Factor
Functionregulating HIF-alpha stability
Amino Acids426 aa
PathwaysNF-κB pathway, Notch signaling
UniProt IDQ9Y2H5
NCBI Gene ID54583
Ensembl IDENSG00000127837
OMIM609424
GeneCardsEGLN1
Human Protein AtlasEGLN1
Associated DiseasesCancer
InteractionsCANCER, GENES, RNA
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.89
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53

Related Analyses (3)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (3)

Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: interacts_with
Genes
index · KG edge: associated_with

Knowledge Graph (12 edges)

EGLN1 interacts_with cancer
CANCER activates EGLN1
EGLN1 interacts_with Ms
EGLN1 activates Cancer
EGLN1 interacts_with Tumor
CANCER interacts_with EGLN1
EGLN1 interacts_with GENES
EGLN1 interacts_with RNA
RNA regulates EGLN1
EGLN1 associated_with Cancer

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