gene 1,645 words KG: EGLN1 2026-03-28
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

EGLN1 — Egl-9 Family Prolyl Hydroxylase 1

🧬 Gene Info
Gene SymbolEGLN1
Full NameEgl-9 Family Prolyl Hydroxylase 1
Chromosome1q42.12
Protein TypeTranscription Factor
Functionregulating HIF-alpha stability
Amino Acids426 aa
PathwaysNF-κB pathway, Notch signaling
UniProt IDQ9Y2H5
NCBI Gene ID54583
Ensembl IDENSG00000127837
OMIM609424
GeneCardsEGLN1
Human Protein AtlasEGLN1
Previous NamesPHD2, EGLN1, PHD1
RegionExpression Level
Associated DiseasesCancer
InteractionsGENES, RNA, CANCER
KG Connections17 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48

Related Analyses (3)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (3)

Genes
index · KG edge: associated_with
Tumor Necrosis Factor (TNF)
entity · KG edge: interacts_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

EGLN1 interacts_with cancer
EGLN1 interacts_with Ms
EGLN1 activates Cancer
EGLN1 interacts_with Tumor
EGLN1 interacts_with GENES
EGLN1 interacts_with RNA
EGLN1 associated_with Cancer
EGLN1 associated_with GENES
EGLN1 regulates RNA
EGLN1 regulates AND