gene 916 words KG: GBA3 2026-03-24
kind:genesection:genesstate:published
Contents

GBA3 — Glucosidase Beta 3

🧬 Gene Info
Gene SymbolGBA3
Full NameGlucosidase Beta 3
Chromosome4p15.2
Protein TypeHydrolase
Functionencodes a member of the glycoside hydrolase family, specifically a lysosomal glucocerebrosidase enzyme.
Amino Acids556 aa
UniProt IDQ9Y5K2
NCBI Gene ID57733
GeneCardsGBA3
Human Protein AtlasGBA3
Official Full NameGlucosidase beta 3
Protein ClassGlycoside hydrolase, family 1
ApproachTarget
Enzyme replacementGBA3 activity
Small molecule activatorsIncrease activity
Associated DiseasesHypertension, Ms
InteractionsSLC22A2, COMT, UGT3A1, CYP2C18, CYP3A5
KG Connections24 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Sphingolipid Metabolism Reprogramming
Score: 0.44
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
Ganglioside Rebalancing Therapy
Score: 0.50
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (5)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
slc22a2
gene · KG edge: associated_with
COMT Gene
gene · KG edge: associated_with
Insulin Receptor Substrate 1 (IRS-1)
entity · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

GBA3 associated_with COMT
GBA3 associated_with SLC22A2
GBA3 regulates Metabolite Levels
GBA3 interacts_with SLC22A2
GBA3 interacts_with COMT
GBA3 associated_with Hypertension
GBA3 associated_with Ms
GBA3 associated_with INSULIN RESISTANCE
GBA3 associated_with AND
GBA3 associated_with UGT3A1