COMT

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

COMT is a protein involved in neurodegeneration research. Key relationships include: associated with, expressed in, co discussed. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 173 entities in the SciDEX knowledge graph.

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flowchart TD
    COMT["COMT Gene<br/>Catechol-O-methyltransferase"]
    COMT_protein["COMT Protein<br/>Dopamine Metabolizing<br/>Enzyme"]
    dopamine["Dopamine<br/>Neurotransmitter"]
    cognitive_function["Cognitive Function<br/>Executive Control<br/>Working Memory"]
    
    SLC6A3["DAT1 (SLC6A3)<br/>Dopamine Transporter"]
    SLC6A2["NET (SLC6A2)<br/>Norepinephrine Transporter"]
    ADRA2A["ADRA2A<br/>Alpha-2A Adrenergic<br/>Receptor"]
    HTR2C["HTR2C<br/>Serotonin 2C Receptor"]
    
    Alzheimer["Alzheimer's Disease<br/>Cognitive Decline"]
    Parkinson["Parkinson's Disease<br/>Motor and Cognitive<br/>Dysfunction"]
    ALS["ALS<br/>Motor Neuron<br/>Degeneration"]
    Depression["Depression<br/>Mood Disorder"]
    Dementia["Dementia<br/>Progressive<br/>Cognitive Loss"]
    
    COMT --|"encodes"|--> COMT_protein
    COMT_protein --|"metabolizes"|--> dopamine
    dopamine --|"regulates"|--> cognitive_function
    
    COMT --|"variants affect"|--> Alzheimer
    COMT --|"variants affect"|--> Parkinson
    COMT --|"contributes to"|--> ALS
    COMT --|"associated with"|--> Depression
    COMT --|"therapeutic target"|--> Dementia
    
    SLC6A3 --|"interacts with"|--> dopamine
    SLC6A2 --|"modulates"|--> COMT_protein
    ADRA2A --|"influences"|--> cognitive_function
    HTR2C --|"cross-regulates"|--> dopamine
    
    cognitive_function --|"impaired in"|--> Alzheimer
    cognitive_function --|"affected in"|--> Parkinson
    dopamine --|"depleted in"|--> Parkinson
    
    style COMT fill:#006494
    style COMT_protein fill:#006494
    style dopamine fill:#4a1a6b
    style cognitive_function fill:#1b5e20
    style SLC6A3 fill:#4a1a6b
    style SLC6A2 fill:#4a1a6b
    style ADRA2A fill:#4a1a6b
    style HTR2C fill:#4a1a6b
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style Depression fill:#ef5350
    style Dementia fill:#ef5350