protein

COMT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

294Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

COMT is a protein involved in neurodegeneration research. Key relationships include: associated with, expressed in, co discussed. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 173 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	COMT
Full Name	Catechol-O-Methyltransferase
Chromosome	22
Protein Type	Enzyme
Function	The COMT gene encodes catechol-O-methyltransferase, an enzyme that catalyzes the methylation of catecholamines using S-adenosylmethionine (SAM) as a methyl donor.
Primary Expression	peripheral tissues
Molecular Weight	30 kDa
Pathways	autophagy pathway
UniProt ID	P21964
Ensembl ID	ENSG00000093072
OMIM	116790
GeneCards	COMT
Human Protein Atlas	COMT
Associated Diseases	age-related cognitive decline, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	levodopa, LEVODOPA
Interactions	ANKK1, APOE, BDNF, CYP2C18, CYP3A5, DAT
SciDEX Hypotheses	Dopaminergic Cognitive Enhancement Hypothesis
KG Connections	294 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: COMT — AlphaFold P21964 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    COMT["COMT Gene
Catechol-O-methyltransferase"]
    COMT_protein["COMT Protein
Dopamine Metabolizing
Enzyme"]
    dopamine["Dopamine
Neurotransmitter"]
    cognitive_function["Cognitive Function
Executive Control
Working Memory"]
    
    SLC6A3["DAT1 (SLC6A3)
Dopamine Transporter"]
    SLC6A2["NET (SLC6A2)
Norepinephrine Transporter"]
    ADRA2A["ADRA2A
Alpha-2A Adrenergic
Receptor"]
    HTR2C["HTR2C
Serotonin 2C Receptor"]
    
    Alzheimer["Alzheimer's Disease
Cognitive Decline"]
    Parkinson["Parkinson's Disease
Motor and Cognitive
Dysfunction"]
    ALS["ALS
Motor Neuron
Degeneration"]
    Depression["Depression
Mood Disorder"]
    Dementia["Dementia
Progressive
Cognitive Loss"]
    
    COMT -->|"encodes"| COMT_protein
    COMT_protein -->|"metabolizes"| dopamine
    dopamine -->|"regulates"| cognitive_function
    
    COMT -->|"variants affect"| Alzheimer
    COMT -->|"variants affect"| Parkinson
    COMT -->|"contributes to"| ALS
    COMT -->|"associated with"| Depression
    COMT -->|"therapeutic target"| Dementia
    
    SLC6A3 -->|"interacts with"| dopamine
    SLC6A2 -->|"modulates"| COMT_protein
    ADRA2A -->|"influences"| cognitive_function
    HTR2C -->|"cross-regulates"| dopamine
    
    cognitive_function -->|"impaired in"| Alzheimer
    cognitive_function -->|"affected in"| Parkinson
    dopamine -->|"depleted in"| Parkinson
    
    style COMT fill:#006494
    style COMT_protein fill:#006494
    style dopamine fill:#4a1a6b
    style cognitive_function fill:#1b5e20
    style SLC6A3 fill:#4a1a6b
    style SLC6A2 fill:#4a1a6b
    style ADRA2A fill:#4a1a6b
    style HTR2C fill:#4a1a6b
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style Depression fill:#ef5350
    style Dementia fill:#ef5350

Outgoing (201)

Target	Relation	Type	Str
Levodopa-Induced Dyskinesia	risk_factor_for	phenotype	0.95
Signal Transmission	involved_in	process	0.90
Levodopa Response	biomarker_for	phenotype	0.90
Parkinson Disease	associated_with	disease	0.90
Metabolite Levels	regulates	phenotype	0.85
Cognition	regulates	phenotype	0.85
Levodopa-induced dyskinesia	risk_factor_for	phenotype	0.85
Chemical synaptic transmission	modulates	process	0.82
Cognitive Aging	risk_factor_for	phenotype	0.80
DRD2	interacts_with	gene	0.80
dopamine	degrades	entity	0.80
Parkinson's disease	associated_with	disease	0.80
hyperuricemia	inhibits	disease	0.80
glioma	associated_with	disease	0.80
Als	associated_with	disease	0.75
Parkinson'S Disease	associated_with	disease	0.75
Parkinson's Disease	implicated_in	disease	0.75
Dementia	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
anxiety	modulates	phenotype	0.75
COMT_protein	encodes	protein	0.72
cognitive_function	associated_with	phenotype	0.72
DBH	transports	gene	0.70
DOPAMINERGIC	regulates	cell_type	0.70
NEURONS	regulates	cell_type	0.70
SLC6A3	expresses	gene	0.70
DRD2	expressed_in	gene	0.70
Cognitive flexibility	regulates	phenotype	0.70
Dopamine clearance in prefrontal cortex	regulates	process	0.70
Attention	regulates	phenotype	0.70
Parkinson's disease	biomarker_for	disease	0.70
age-related cognitive decline	associated_with	phenotype	0.70
ALS	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
dopamine	regulates	protein	0.64
BDNF	contributes_to	gene	0.60
GBA3	associated_with	gene	0.60

Incoming (93)

Source	Relation	Type	Str
LEVODOPA	activates	drug	0.70
PARKINSON	associated_with	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
levodopa	targets	drug	0.70
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
FYN	associated_with	gene	0.60
SRC	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
UBC	associated_with	gene	0.60
HOMER1	associated_with	gene	0.60
GBA3	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
APOE	co_discussed	gene	0.60
CHAT	co_discussed	gene	0.60
BDNF	co_discussed	gene	0.60
PENK	expressed_in	gene	0.60
NCAM1	expressed_in	gene	0.60
DNMT1	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
MTOR	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
SLC6A4	expressed_in	gene	0.60
DICER1	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC6A3	causes	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SLC22A2	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
SNCA	causes	gene	0.60
MAPT	causes	gene	0.60
HSP90AA1	associated_with	gene	0.60
ABCG2	associated_with	entity	0.60
DEPRESSION	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Dopaminergic Cognitive Enhancement Hypothesis	0.000	-	Unable to extract research questions - t

Mentioning Analyses (2)

Scientific analyses that reference this entity

Unable to extract research questions - transcript appears to be empty

methodology | 2026-04-04 | 7 hypotheses Top: 0.512

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 10 hypotheses Top: 0.829

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The provided transcript contains only speaker labels [Theorist] and [Synthesizer

closed · Rounds: 4 · Score: 0.95 · 2026-04-13

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04

Related Research

Hypotheses and analyses mentioning COMT in their description or question text

No additional research found

COMT

Understanding Entity Pages

Summary

Wiki Pages (5)

Opicapone (Ongentys)

COMT Inhibitors

COMT Gene

COMT Protein

Dopamine Metabolism Enzymes Beyond COMT

Pathway Diagram

Outgoing (201)

Incoming (93)

Targeting Hypotheses (1)

Mentioning Analyses (2)

Unable to extract research questions - transcript appears to be empty

Which metabolic biomarkers can distinguish therapeutic response from disease pro

Experiments (0)

Related Papers (0)

Debates (2)

The provided transcript contains only speaker labels [Theorist] and [Synthesizer

Which metabolic biomarkers can distinguish therapeutic response from disease pro

Related Research