| Gene Symbol | COMT |
| Full Name | Catechol-O-Methyltransferase |
| Chromosome | 22 |
| Protein Type | Enzyme |
| Function | The COMT gene encodes catechol-O-methyltransferase, an enzyme that catalyzes the methylation of catecholamines using S-adenosylmethionine (SAM) as a methyl donor. |
| Primary Expression | peripheral tissues |
| Molecular Weight | 30 kDa |
| Pathways | autophagy pathway |
| UniProt ID | P21964 |
| Ensembl ID | ENSG00000093072 |
| OMIM | 116790 |
| GeneCards | COMT |
| Human Protein Atlas | COMT |
| Genomic Location | 22q11.21 |
| Entacapone | Selective, peripheral |
| Associated Diseases | ALS, Alzheimer, Alzheimer'S Disease, Anxiety |
| Known Drugs/Compounds | levodopa, LEVODOPA |
| Interactions | SLC6A4, GBA3, SLC22A2, DRD2, SLC6A3, GENES |
| KG Connections | 276 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |