gene 5,408 words KG: GRIA3 2026-03-27
kind:genesection:genesstate:published
Contents

GRIA3 Gene

🧬 Gene Info
Gene SymbolGRIA3
ChromosomeXq21.3
Protein FamilyAMPA receptor family, ionotropic glutamate receptor family
FunctionAMPA receptors containing GluA3 subunits mediate fast excitatory neurotransmission at the vast majority of synapses in the brain.
Subcellular LocalizationPostsynaptic membrane, synapse
Molecular Weight100 kDa
Amino Acids894 aa
Exons22
PathwaysCamp Signaling
UniProt ID[P42263](https://www.uniprot.org/uniprot/P42263)
GeneCardsGRIA3
Human Protein AtlasGRIA3
Genomic Span~50 kb
Number of Exons22
Transcript Length~4.5 kb (coding sequence)
Associated DiseasesNeurodegeneration
KG Connections37 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Stress-induced depression model sleep architecture analysis
validation · proposed · Score: 0.90

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: therapeutic_target
Dementia Australia
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with

Knowledge Graph (12 edges)

GRIA3 therapeutic_target KCNK2
GRIA3 regulates PDE4D
GRIA3 regulates MAPT
GRIA3 regulates EGFR
GRIA3 regulates CLU
GRIA3 regulates Rb
GRIA3 therapeutic_target Schizophrenia
GRIA3 therapeutic_target Als
GRIA3 therapeutic_target Autism
GRIA3 therapeutic_target Depression