| Gene Symbol | PDE4D |
| Full Name | Phosphodiesterase 4D (cAMP-specific) |
| Aliases | Phosphodiesterase 4D |
| Chromosome | 5q12.1 |
| Function | is a member of the phosphodiesterase 4 (PDE4) family that specifically hydrolyzes cyclic adenosine monophosphate (cAMP), serving as a key regulator of cAMP signaling in cells. |
| Primary Expression | Brain (cortex, hippocampus, cerebellum), immune cells, smooth muscle |
| Subcellular Localization | Isoform expression varies by brain region and cell type |
| Amino Acids | 886 aa |
| Pathways | Camp Signaling |
| UniProt ID | Q08499 |
| NCBI Gene ID | 5145 |
| Ensembl ID | ENSG00000100162 |
| OMIM | 600129 |
| GeneCards | PDE4D |
| Human Protein Atlas | PDE4D |
| Associated Diseases | neurodegeneration |
| Interactions | SIRT1, PDE4B, PARKIN, CREB1, PER, GENES |
| KG Connections | 55 knowledge graph edges |
| Databases | GeneCardsHPASTRING |