concept

APP/PS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APP/PS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1340Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

APP/PS1 is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, Aging, Als. Connected to 440 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	APP/PS1
Key Genes/Proteins	APP, NEUROINFLAMMATION, ALZHEIMER, AMYLOID, ALZHEIMER'S DISEASE, MICROGLIA
Related Diseases	Alzheimer, Neuroinflammation, Inflammation, Als, Aging

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    APP_PS1 -->|"regulates"| Alzheimer["Alzheimer"]
    APP_PS1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    APP_PS1 -->|"regulates"| Ms["Ms"]
    APP_PS1 -->|"regulates"| Als["Als"]
    APP_PS1 -->|"inhibits"| Dementia["Dementia"]
    MICROGLIA["MICROGLIA"] -->|"regulates"| APP_PS1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| APP_PS1
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| APP_PS1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| APP_PS1
    P62["P62"] -->|"regulates"| APP_PS1
    LAMP1["LAMP1"] -->|"regulates"| APP_PS1
    RHOA["RHOA"] -->|"regulates"| APP_PS1
    PDE4B["PDE4B"] -->|"inhibits"| APP_PS1

Outgoing (797)

Target	Relation	Type	Str
APP	inhibits	gene	1.00
Alzheimer	activates	disease	1.00
APP	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Neuroinflammation	activates	disease	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
ALZHEIMER	activates	gene	1.00
AMYLOID	activates	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
MICROGLIA	activates	gene	1.00
Aging	activates	disease	0.95
Alzheimer	protects_against	disease	0.95
Neurodegeneration	activates	disease	0.95
Alzheimer	treats	disease	0.95
Cognitive Impairment	causes	phenotype	0.90
Alzheimer Disease	causes	disease	0.90
Alzheimer'S Disease	associated_with	disease	0.90
Amyloid plaque load	associated_with	biomarker	0.90
Apoptosis	activates	pathway	0.90
Autophagy	activates	pathway	0.90
ALZHEIMER	protects_against	gene	0.90
NEURON	activates	gene	0.90
AMYLOID	inhibits	gene	0.90
INFLAMMATION	activates	gene	0.90
ALZHEIMER	treats	gene	0.90
ALZHEIMER'S DISEASE	treats	gene	0.90
Alzheimer	associated_with	disease	0.85
Inflammation	inhibits	disease	0.85
Neuroinflammation	inhibits	disease	0.85
Neuroinflammation	treats	disease	0.85
Inflammation	treats	disease	0.85
Amyloid Deposition	causes	phenotype	0.85
Apoptosis	inhibits	pathway	0.80
AMPK	activates	gene	0.80
Mitophagy	activates	pathway	0.80
APP	protects_against	gene	0.80
NEUROINFLAMMATION	inhibits	gene	0.80
SIRT3	activates	gene	0.80
AGING	activates	gene	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.80
ALZHEIMER	associated_with	gene	0.80
LC3	activates	gene	0.80
NF-ΚB	activates	gene	0.80
Nf-Κb	activates	pathway	0.80
Inflammasome	activates	pathway	0.80
ALZHEIMER'S DISEASE	protects_against	gene	0.80
GENES	activates	gene	0.80
NEUROINFLAMMATION	treats	gene	0.80
Alzheimer	inhibits	disease	0.75

Incoming (543)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
NLRP3	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
Chronic Cerebral Hypoperfusion	contributes_to	process	0.80
MITOPHAGY	activates	gene	0.80
TLR4	activates	gene	0.80
TAU	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
APOPTOSIS	inhibits	gene	0.80
TNF	inhibits	gene	0.70
APP	activates	gene	0.70
ROS	activates	gene	0.70
BMAL1	expressed_in	gene	0.70
AMYLOID	activates	gene	0.70
APP	associated_with	gene	0.70
NEURODEGENERATION	protects_against	gene	0.70
BCL-2	associated_with	gene	0.60
MICROGLIA	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
P62	regulates	gene	0.60
LAMP1	regulates	gene	0.60
RHOA	regulates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
PDE4B	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
GFAP	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
RAGE	inhibits	gene	0.60
CASP1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Β-HYDROXYBUTYRATE	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
MICROGLIA	associated_with	gene	0.60
SIRT3	activates	gene	0.60
GSK3A	activates	gene	0.60
AGING	activates	gene	0.60
CTSB	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CTSL	activates	gene	0.60
CTSS	inhibits	gene	0.60
JAK2	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
SNAP23	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
GFAP	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
AMYLOID-BETA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

APP/PS1

Understanding Entity Pages

Summary

Wiki Pages (20)

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