gene 615 words KG: KCNJ6 2026-03-16
kind:genesection:genesstate:published
Contents

KCNJ6 — Potassium Inwardly Rectifying Channel Subfamily J Member 6

🧬 Gene Info
Gene SymbolKCNJ6
Full NamePotassium Inwardly Rectifying Channel Subfamily J Member 6
AliasesKir3.2 Potassium Channel
Chromosome21q22.12
Protein TypeChannel
FunctionKCNJ6 (also known as Kir2.3 or GIRK2) is an inward rectifier potassium channel subunit highly expressed in the brain, particularly in dopaminergic neurons of the substantia nigra
Primary Expressionthe brain, particularly in dopaminergic neurons of the substantia nigra
Molecular Weight48 kDa
UniProt IDP48051
NCBI Gene ID3767
Ensembl IDENSG00000157542
OMIM600726
GeneCardsKCNJ6
Human Protein AtlasKCNJ6
StrategyDrug/Approach
Associated DiseasesCancer, Ms
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: expressed_in
STRAP — Serine Threonine Kinase Receptor Associated Pro
gene · KG edge: expressed_in
SPTLC1 - Serine Palmitoyltransferase
gene · KG edge: expressed_in
KCNS1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

KCNJ6 regulates KCNJ5
KCNJ6 regulates KCNJ3
KCNJ6 regulates KCNK2
KCNJ6 regulates KCNS1
KCNJ6 expressed_in STRAP
KCNJ6 expressed_in SPTLC1
KCNJ6 expressed_in JAG2
KCNJ6 associated_with CANCER
KCNJ6 associated_with Ms
KCNJ6 associated_with Cancer