| Gene Symbol | KCNJ3 |
| Protein Type | Protein |
| Function | The activation mechanism involves |
| Molecular Weight | 57 kDa |
| Amino Acids | 497 aa |
| UniProt ID | Search UniProt |
| GeneCards | KCNJ3 |
| Human Protein Atlas | KCNJ3 |
| Transmembrane Domains | Two transmembrane helices (M1 and M2) that span the neuronal membrane |
| Pore Region (H5/P-loop) | Located between M1 and M2, contains the K⁺ selectivity filter (GYG motif) |
| N-terminus | Contains the Gβγ binding site and regulates channel trafficking |
| C-terminus | Contains the PIP₂ binding site essential for channel activation, palmitoylation sites, and PDZ-domain interactions |
| Basal Ganglia | Critical modulation of dopaminergic neuron firing in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA); regulates reward processing5] |
| and motor control [Cerebellum | Modulates Purkinje cell output and cerebellar learning; regulates inhibitory interneuron function [6] |
| [Cortex](/brain-regions/cortex) | Controls pyramidal neuron excitability and sensory integration |
| Associated Diseases | Cancer, Ms |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |