| Gene Symbol | KCNS1 |
| Protein Type | Channel |
| Function | encodes a voltage-gated potassium channel subunit that plays important roles in neuronal excitability, pain signaling, and synaptic transmission. |
| GeneCards | KCNS1 |
| Human Protein Atlas | KCNS1 |
| Slow Activation Kinetics | Channels activate more slowly than typical delayed rectifiers |
| Depolarized Activation | Requires stronger depolarization for activation |
| Modulation Sensitivity | Enhanced responsiveness to intracellular signaling pathways |
| Brain | Highest expression in cortex, hippocampus, and thalamus |
| Spinal Cord | Dorsal horn neurons involved in pain processing |
| Sensory Ganglia | Dorsal root ganglion neurons |
| Peripheral Nervous System | Various neuronal populations |
| Action Potential Repolarization | Contributes to the delayed rectifier current |
| Firing Frequency | Modulates neuronal output and firing patterns |
| Resting Membrane Potential | Helps maintain stable resting potential |
| Associated Diseases | Cancer, Ms |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |