gene 554 words KG: LRP3
Contents

LRP3 — Low Density Lipoprotein Receptor-Related Protein 3

🧬 Gene Info
Gene SymbolLRP3
Full NameLow Density Lipoprotein Receptor-Related Protein 3
Chromosome19q13.31
Protein FamilyLDLR receptor family
Protein TypeReceptor
FunctionLRP-family proteins typically combine extracellular ligand-binding domains with transmembrane and cytoplasmic motifs that support ligand uptake, trafficking, and downstream signaling.[@herz2001] Withi
Primary ExpressionBrain (cortex, hippocampus), heart, skeletal muscle
Molecular Weight250 kDa
Amino Acids325 aa
UniProt IDO75074
NCBI Gene ID4037
Ensembl IDENSG00000186603
GeneCardsLRP3
Human Protein AtlasLRP3
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (45)

Lysosomal Membrane Repair Enhancement
Score: 0.54
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
← Prevpg 3/3

Related Analyses (22)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 4 hypotheses
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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