gene 3,305 words KG: MAPK9
Contents

MAPK9 Gene

🧬 Gene Info
Gene SymbolMAPK9
Chromosome5q33.1
Functionis a critical regulator of cellular stress responses, inflammation, cell proliferation, and apoptosis.
Primary Expressionvarious tissues, JNK3 (MAPK10) is primarily expressed in neurons
Molecular Weight48 kDa
Amino Acids424 aa
Exons18
PathwaysMAPK, NF-κB
GeneCardsMAPK9
Human Protein AtlasMAPK9
Genomic position~179,500,000-179,560,000 (GRCh38)
Exon count18 exons
Protein lengthVaries by isoform (JNK2α: 424 amino acids; JNK2β: 427 amino acids)
Molecular weightApproximately 46-48 kDa
Cellular stressUV radiation, oxidative stress, cytokines
Associated DiseasesAlzheimer, Ms
KG Connections14 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
TFEB (Redirect)
redirect · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
Genes
index · KG edge: associated_with
BAX Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

BAX associated_with MAPK9
MAPK9 associated_with TFEB
MAPK9 associated_with BAX
ALZHEIMER'S DISEASE associated_with MAPK9
MAPK9 associated_with AUTOPHAGY
MAPK9 associated_with OXIDATIVE STRESS
MAPK9 associated_with Alzheimer
MAPK9 associated_with Ms
MAPK9 associated_with Autophagy
MAPK9 associated_with Mapk

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.