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gene 1,780 words KG: BAX
Contents

BAX Gene

🧬 Gene Info
Gene SymbolBAX
Chromosome19q13.33
Protein FamilyBCL-2 family (BH3-only pro-apoptotic)
Functionis a critical pro-apoptotic member of the BCL-2 protein family that plays a central role in regulating mitochondrial apoptosis.
Subcellular LocalizationCytosol (inactive), Mitochondria (active), ER
Molecular Weight21 kDa (192 amino acids)
Amino Acids192 aa
PathwaysAkt, Apoptosis, Autophagy, Cell Division, Cholesterol
UniProt IDQ07812
Ensembl IDENSG00000087088
GeneCardsBAX
Human Protein AtlasBAX
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Ataxia
Known Drugs/CompoundsABT-263, ANTHOCYANINS, berberine, BERBERINE, B.glomerulata, cadmium
InteractionsABCG2, ACHE, ACSL4, ADAM8, AGING, AIF
KG Connections2336 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.83Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.88Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.86

Related Analyses (9)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activatesACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibitsACVR2A Gene
gene · KG edge: regulatesADAM8 Gene
gene · KG edge: inhibitsAIFM1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CLU interacts_with BAX
BAX associated_with EHMT2
BAX inhibits JUN
BAX associated_with FOXO1
BAX associated_with BCL2
FASN inhibits BAX
BAX inhibits ALOX15
BAX inhibits GSDMD
BAX inhibits SCD1
BAX inhibits HMGCR

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