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gene 1,780 words KG: BAX
Contents

BAX Gene

🧬 Gene Info
Gene SymbolBAX
Chromosome19q13.33
Protein FamilyBCL-2 family (BH3-only pro-apoptotic)
Functionis a critical pro-apoptotic member of the BCL-2 protein family that plays a central role in regulating mitochondrial apoptosis.
Subcellular LocalizationCytosol (inactive), Mitochondria (active), ER
Molecular Weight21 kDa (192 amino acids)
Amino Acids192 aa
PathwaysAkt, Apoptosis, Autophagy, Cell Division, Cholesterol
UniProt IDQ07812
Ensembl IDENSG00000087088
GeneCardsBAX
Human Protein AtlasBAX
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Ataxia
Known Drugs/CompoundsABT-263, ANTHOCYANINS, berberine, BERBERINE, B.glomerulata, cadmium
InteractionsABCG2, ACHE, ACSL4, ADAM8, AGING, AIF
KG Connections2396 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (44)

Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78Transcriptional Autophagy-Lysosome Coupling
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
pg 1/3Next →

Related Analyses (9)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activatesACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibitsACVR2A Gene
gene · KG edge: regulatesADAM8 Gene
gene · KG edge: inhibitsAIFM1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CLU interacts_with BAX
BAX associated_with EHMT2
BAX inhibits JUN
FASN inhibits BAX
BAX inhibits ALOX15
BAX inhibits GSDMD
BAX inhibits SCD1
BAX inhibits HMGCR
BAX inhibits TNF
BAX inhibits MLKL

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