gene 1,223 words KG: MTCL1 2026-03-25
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

MTCL1 — Microtubule Cross-Linking Factor 1

🧬 Gene Info
Gene SymbolMTCL1
Full NameMTCL1 — Microtubule Cross-Linking Factor 1
Chromosome21q22.3
Protein TypeGene
Functionis a human gene encoding a microtubule-associated protein (MAP) that promotes microtubule bundling and stabilization in cells[@shorabe2005].
Primary Expressionthe brain, where it plays critical roles in neuronal polarity, axonal transport, and dendritic spine morphogenesis
Molecular Weight230 kDa
Amino Acids104 aa
Exons35
PathwaysCOMPLEMENT, Complement, Epigenetic, Wnt
NCBI Gene IDSearch NCBI
GeneCardsMTCL1
Human Protein AtlasMTCL1
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsC1Q, UBIQUITIN, Rb, C1QBP, WNT, RNA
KG Connections35 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (6)

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.49
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.38
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.48
Cross-Seeding Prevention Strategy
Score: 0.45
Low Complexity Domain Cross-Linking Inhibition
Score: 0.42

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (5)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: activates
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: activates
Proteasome-Ubiquitin System Dysfunction Validation in P
experiment · KG edge: inhibits
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates

Knowledge Graph (12 edges)

MTCL1 encodes circMTCL1
MTCL1 activates C1Q
MTCL1 activates UBIQUITIN
MTCL1 inhibits UBIQUITIN
MTCL1 regulates UBIQUITIN
MTCL1 degrades UBIQUITIN
MTCL1 inhibits Rb
MTCL1 inhibits C1QBP
MTCL1 activates Carcinoma
MTCL1 activates Ms