gene 1,447 words KG: NDUFAF1 2026-03-21
kind:genesection:genesstate:published
Contents

NDUFAF1 — NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 1

🧬 Gene Info
Gene SymbolNDUFAF1
Full NameNADH:Ubiquinone Oxidoreductase Complex Assembly Factor 1
Chromosome16p13.3
Protein FamilyAIM (Ancestral Immune Protein) family
Functionis a nuclear-encoded mitochondrial protein that plays a critical role in the biogenesis of mitochondrial Complex I, the largest enzyme of the electron transport chain.
Primary ExpressionBrain, heart, skeletal muscle, liver, kidney
Subcellular LocalizationMitochondrial matrix
Molecular Weight46 kDa
Amino Acids90 aa
UniProt ID[Q9P032](https://www.uniprot.org/uniprot/Q9P032)
Ensembl IDENSG00000166068
GeneCardsNDUFAF1
Human Protein AtlasNDUFAF1
Associated DiseasesMs
KG Connections15 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (1)

HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44

Related Analyses (2)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (8)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
NDUFAF7 Gene
gene · KG edge: associated_with
NBR1 Gene
gene · KG edge: associated_with
Mitofusin 1 (MFN1)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NDUFAF1 associated_with MFN1
NDUFAF1 associated_with NBR1
NDUFAF1 associated_with BNIP3
NDUFAF1 associated_with MCC
NDUFAF1 associated_with NDUFAF7
NDUFAF1 associated_with IMMUNE INFILTRATION
NDUFAF1 associated_with Ms
NDUFAF1 associated_with B Cell
NDUFAF1 associated_with Ras
NDUFAF1 associated_with App