gene 668 words KG: MFN1 2026-03-22
kind:genesection:genesstate:published
Contents

Mitofusin 1 (MFN1)

🧬 Gene Info
Gene SymbolMFN1
Chromosome3q26.33
FunctionMitofusin 1 (MFN1) is a dynamin-like GTPase essential for mitochondrial outer membrane fusion
Primary Expressionhippocampus, Cerebellum, Cortex, Striatum, Substantia Nigra
Molecular Weight83 kDa
PathwaysApoptosis, Autophagy, Epigenetic, Lysosomal Degradation, Mitochondrial Function
GeneCardsMFN1
Human Protein AtlasMFN1
Associated DiseasesAD, ALI, ALS, Alzheimer, COPD
InteractionsERN1, PARKIN, FMR1, SNCA, FAM134B, LC3
KG Connections931 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (7)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: co_discussed
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

MFN1 interacts_with ERN1
MFN1 interacts_with PARKIN
MFN1 interacts_with FMR1
MFN1 interacts_with SNCA
MFN1 interacts_with FAM134B
MFN1 interacts_with LC3
MFN1 interacts_with EPAS1
MFN1 interacts_with MIRO1
MFN1 interacts_with CTSD
MFN1 interacts_with RB1