gene 668 words KG: MFN1
Contents

Mitofusin 1 (MFN1)

🧬 Gene Info
Gene SymbolMFN1
Chromosome3q26.33
FunctionMitofusin 1 (MFN1) is a dynamin-like GTPase essential for mitochondrial outer membrane fusion
Primary Expressionhippocampus, Cerebellum, Cortex, Striatum, Substantia Nigra
Molecular Weight83 kDa
PathwaysApoptosis, Autophagy, Epigenetic, Lysosomal Degradation, Mitochondrial Function
GeneCardsMFN1
Human Protein AtlasMFN1
Associated DiseasesAD, ALI, Als, Alzheimer, COPD
InteractionsABCD3, Actin, AGING, AKT, ALS, ALZHEIMER
KG Connections921 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
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Related Analyses (10)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: co_discussed
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

CAT interacts_with MFN1
OPTN interacts_with MFN1
DNM1L interacts_with MFN1
CANX interacts_with MFN1
LGALS3 interacts_with MFN1
CALCOCO2 interacts_with MFN1
G3BP1 interacts_with MFN1
PEX3 interacts_with MFN1
SQSTM1 interacts_with MFN1
BCL2 interacts_with MFN1

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