gene 672 words KG: BNIP3 2026-03-21
kind:genesection:genesstate:published
Contents

BNIP3 Gene

🧬 Gene Info
Gene SymbolBNIP3
Full NameBCL2 Interacting Protein 3
Chromosome10q26.3
Functionis a pro-apoptotic BH3-only protein that plays a dual role in regulating both apoptosis and mitophagy.
Primary ExpressionUbiquitous; high expression in brain, heart, and skeletal muscle
PathwaysApoptosis, Autophagy, Chaperone, Histone Modification, Lipid Metabolism
UniProt IDQ12986
NCBI Gene ID664
Ensembl IDENSG00000176171
OMIM604488
GeneCardsBNIP3
Human Protein AtlasBNIP3
Associated DiseasesAD, ALI, ALS, Alzheimer, Carcinoma
Known Drugs/Compoundsdimethyl fumarate
InteractionsDISC1, EIF2S1, RIPK3, DRP1, CHOP, BECN1
KG Connections1281 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (14)

Mitochondrial transfer between neurons and glia
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

BNIP3 interacts_with DISC1
BNIP3 interacts_with EIF2S1
BNIP3 interacts_with RIPK3
BNIP3 interacts_with DRP1
BNIP3 interacts_with CHOP
BNIP3 interacts_with BECN1
BNIP3 interacts_with PTEN
BNIP3 interacts_with DDIT3
BNIP3 interacts_with NBR1
BNIP3 interacts_with EMD