gene 2,606 words KG: NDUFS8 2026-03-27
kind:genesection:genesstate:publishedtopic:mitochondriatopic:complex-itopic:parkinsons-diseasetopic:iron-sulfur-cluster
Contents

NDUFS8 — NADH:Ubiquinone Oxidoreductase Core Subunit S8

🧬 Gene Info
Gene SymbolNDUFS8
Full NameNADH:Ubiquinone Oxidoreductase Core Subunit S8 (TYKY)
Chromosome19q13.42
Functionencodes a critical iron-sulfur protein subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase), the largest and most complex enzyme of the mitochondrial electron transport chain.
Primary ExpressionBrain, Heart, Skeletal Muscle, Liver, Kidney
Molecular Weight23 kDa
Amino Acids210 aa
Exons5
UniProt IDP51970
NCBI Gene ID4728
Ensembl IDENSG00000110717
OMIM602140
GeneCardsNDUFS8
Human Protein AtlasNDUFS8
Protein Length210 amino acids
Associated DiseasesParkinson's Disease, Leigh Syndrome, Mitochondrial Complex I Deficiency
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49
VCP-Mediated Autophagy Enhancement
Score: 0.41
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (19)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (10)

Alzheimer Indonesia
institution · KG edge: expressed_in
MAPT (Microtubule-Associated Protein Tau) Gene
gene · KG edge: regulates
LDLR Gene
gene · KG edge: expressed_in
HK2
gene · KG edge: biomarker_for
CLU — Clusterin (Apolipoprotein J)
gene · KG edge: regulates

Knowledge Graph (12 edges)

NDUFS8 expressed_in LDLR
NDUFS8 regulates CLU
NDUFS8 regulates SPG7
NDUFS8 regulates MAPT
NDUFS8 expressed_in ACE
NDUFS8 expressed_in ALZHEIMER'S DISEASE
NDUFS8 expressed_in CYTOKINES
NDUFS8 expressed_in ALZHEIMER DISEASE
NDUFS8 expressed_in MITOCHONDRIAL DYSFUNCTION
NDUFS8 expressed_in Alzheimer