gene 1,954 words KG: HK2 2026-03-24
kind:genesection:genesstate:published
Contents

HK2

🧬 Gene Info
Gene SymbolHK2
Full NameHexokinase 2
Chromosome2p12
Protein TypeEnzyme
Target ClassEnzyme
FunctionSmall molecule inhibitor of glucose phosphorylation
Mechanism of ActionSmall molecule inhibitor of glucose phosphorylation
Primary ExpressionBrain, Muscle, Fat
DruggabilityLow (0.38)
Clinical StagePhase III
PathwaysAkt, Apoptosis, Epigenetic, Erk Signaling, Glucose Metabolism
UniProt IDP19367
NCBI Gene ID3099
Ensembl IDENSG00000149718
GeneCardsHK2
Human Protein AtlasHK2
Associated DiseasesALS, Acute Kidney Injury, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/CompoundsADUCANUMAB, aducanumab
InteractionsMYC, FASN, HK1, AKT, SRC, SPR
SciDEX TargetView Target Profile (10 clinical trials)
SciDEX HypothesesMetabolic Switch Targeting for A1→A2 Repolarizatio
Metabolic Reprogramming via Microglial Glycolysis
KG Connections810 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Driven Microglial Metabolic Reprogramming in Synaptic P
Score: 0.64
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (8)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (7)

mtROS effects on TFAM and mtDNA in HK2 cells
exploratory · proposed · Score: 0.90
TFAM knockdown functional analysis
exploratory · proposed · Score: 0.85
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.46
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.46
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.46

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: activates
AKT1 Gene
gene · KG edge: phosphorylates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: activates

Knowledge Graph (12 edges)

HK2 associated_with neurodegeneration
HK2 co_discussed MIRO1
HK2 co_discussed P2RY1
HK2 co_discussed SOAT1
HK2 co_discussed KCNK2
HK2 co_discussed TET2
HK2 co_discussed PIEZO1
HK2 co_discussed P2RX7
HK2 co_discussed DGAT1
HK2 co_discussed C3