| Gene Symbol | SMAD3 |
| Full Name | SMAD Family Member 3 |
| Chromosome | 15q22.33 |
| Protein Type | Transcription Factor |
| Function | encodes a transcription factor that serves as a central mediator of TGF-β (Transforming Growth Factor Beta) signaling. |
| Primary Expression | Brain (cortex, hippocampus, substantia nigra), Lung, Heart, Blood vessels |
| Molecular Weight | 48 kDa |
| Pathways | TGF-β, TGF-β signaling |
| UniProt ID | P84022 |
| NCBI Gene ID | 4088 |
| Ensembl ID | ENSG00000166949 |
| OMIM | 603109 |
| GeneCards | SMAD3 |
| Human Protein Atlas | SMAD3 |
| Associated Diseases | ALS, Aging, Alzheimer, Crohn'S Disease, Diabetes |
| Known Drugs/Compounds | lycopene |
| Interactions | ADAMTS4, AKT, BNIP3L, LC3, TNF, BRD4 |
| KG Connections | 374 knowledge graph edges |
| Databases | GeneCardsHPASTRING |