| Gene Symbol | NFAT2 |
| Full Name | Nuclear Factor of Activated T Cells 2 |
| Aliases | Nuclear Factor of Activated T-Cells 2 |
| Chromosome | 18q23 |
| Protein Type | Transcription Factor |
| Function | NFAT2 functions as a calcium-dependent transcription factor with diverse roles across multiple organ systems. |
| Primary Expression | neurons, astrocytes, and microglia, where it transduces calcium signals into gene expression changes that influence neurodegenerative processes |
| Molecular Weight | 99 kDa |
| Pathways | calcium signaling |
| Ensembl ID | ENSG00000106436 |
| GeneCards | NFAT2 |
| Human Protein Atlas | NFAT2 |
| DNA Binding | NFAT2 binds to NFAT response elements (TGTTTCCA motifs) in the promoters and enhancers of target genes. |
| Co-factor Interactions | NFAT2 interacts with various co-activators and co-repressors to modulate transcription. |
| Alternative Splicing | Multiple NFAT2 isoforms with distinct transcriptional properties are generated through alternative splicing. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | PP2B, NFAT1 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |