Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about T cells: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | T cells |
| Also Known As | T lymphocytes, CD4+ T cells, CD8+ T cells, Regulatory T cells |
| Key Pathways | TCR signaling, IL-2/JAK-STAT, IFN-gamma production, TNF-alpha, TGF-beta/Treg axis |
| Associated Diseases | Alzheimer's disease (neuroinflammation), Multiple sclerosis (autoimmune), Parkinson's disease (alpha-syn-reactive T cells), HIV/AIDS, Autoimmune encephalitis |
| Related Genes | PD-L1, CD8, TCR, CD33, Inflammatory Factors, CD4 |
| Linked Hypotheses | 98 hypotheses |
Knowledge base pages for this entity
graph TD
T_cells["T cells"] -->|"regulates"| Inflammatory_Factors["Inflammatory Factors"]
style Inflammatory_Factors fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
T_cells["T cells"] -->|"infiltrates"| ALS["ALS"]
style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
T_cells["T cells"] -->|"regulates"| Amyloid_plaque_accumulation["Amyloid plaque accumulation"]
style Amyloid_plaque_accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
T_cells["T cells"] -->|"activates"| neuroinflammation["neuroinflammation"]
style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
T_cells["T cells"] -->|"infiltrates"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
style amyotrophic_lateral_sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
T_cells["T cells"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
T_cells["T cells"] -.->|"inhibits"| necroptosis["necroptosis"]
style necroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
PD_L1["PD-L1"] -.->|"inhibits"| T_cells["T cells"]
style PD_L1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
CD8["CD8"] -->|"associated"| T_cells["T cells"]
style CD8 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
CD4["CD4"] -->|"associated"| T_cells["T cells"]
style CD4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
TCR["TCR"] -->|"expressed in"| T_cells["T cells"]
style TCR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
RNA["RNA"] -->|"expressed in"| T_cells["T cells"]
style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style T_cells fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammatory Factors | upregulates | protein | 0.80 |
| ALS | infiltrates | disease | 0.80 |
| Amyloid plaque accumulation | regulates | process | 0.70 |
| neuroinflammation | activates | disease | 0.70 |
| amyotrophic lateral sclerosis | infiltrates | disease | 0.70 |
| Parkinson's disease | associated_with | disease | 0.70 |
| Parkinson's disease | expressed_in | disease | 0.60 |
| necroptosis | inhibits | process | 0.60 |
| multiple sclerosis | causes | disease | 0.60 |
| NF-kB signaling | active_in | pathway | 0.55 |
| pyroptosis | active_in | pathway | 0.55 |
| oxidative stress response | active_in | pathway | 0.55 |
| mitochondrial function | active_in | pathway | 0.55 |
| calcium signaling | active_in | pathway | 0.55 |
| circadian regulation | active_in | pathway | 0.55 |
| NAD+ metabolism | active_in | pathway | 0.55 |
| TGF-beta signaling | active_in | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PD-L1 | inhibits | protein | 0.90 |
| CD8 | associated_with | gene | 0.90 |
| CD4 | associated_with | gene | 0.90 |
| TCR | expressed_in | gene | 0.90 |
| RNA | expressed_in | gene | 0.90 |
| GBM | expressed_in | gene | 0.90 |
| DNA | expressed_in | gene | 0.90 |
| CD33 | expressed_in | gene | 0.90 |
| CD4 | regulates | gene | 0.80 |
| CD4 | expressed_in | gene | 0.80 |
| CD8 | activates | gene | 0.80 |
| CD8 | expressed_in | gene | 0.80 |
| neurodegeneration | affects | disease | 0.80 |
| multiple sclerosis | affects | disease | 0.80 |
| NAD | expressed_in | gene | 0.80 |
| IFN | expressed_in | gene | 0.80 |
| TNF | expressed_in | gene | 0.80 |
| spinal muscular atrophy | affects | disease | 0.80 |
| CD8 | modulates | gene | 0.80 |
| APOE | associated_with | gene | 0.80 |
| AQP4 | associated_with | gene | 0.70 |
| NAD | activates | gene | 0.70 |
| CD8 | inhibits | gene | 0.70 |
| CD8 | implicated_in | gene | 0.70 |
| Parkinson's disease | affects | disease | 0.70 |
| CD4 | activates | gene | 0.70 |
| unfolded protein response | active_in | pathway | 0.70 |
| CXCL10 | activates | gene | 0.70 |
| TNF | activates | gene | 0.70 |
| TNF | regulates | gene | 0.70 |
| GBM | regulates | gene | 0.70 |
| neuroinflammation | affects | disease | 0.70 |
| glioblastoma | affects | disease | 0.70 |
| IFN | activates | gene | 0.70 |
| IFN | inhibits | gene | 0.70 |
| AMPK | expressed_in | gene | 0.70 |
| ATP | expressed_in | gene | 0.70 |
| ROS | expressed_in | gene | 0.70 |
| CD19 | expressed_in | gene | 0.70 |
| PD1 | expressed_in | gene | 0.70 |
| CD4 | modulates | gene | 0.70 |
| CD8 | biomarker_for | gene | 0.70 |
| CD28 | expressed_in | gene | 0.70 |
| NOTCH1 | expressed_in | gene | 0.70 |
| GDNF | expressed_in | gene | 0.70 |
| CCL4 | expressed_in | gene | 0.70 |
| TFEB | expressed_in | gene | 0.70 |
| AQP4 | activates | gene | 0.60 |
| AQP4 | expressed_in | gene | 0.60 |
| TET2 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
cell biology | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||