cell_type

T cells

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about T cells: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

853Connections
0Hypotheses
5Analyses
17Outgoing
50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info
Cell TypeT cells
Also Known AsT lymphocytes, CD4+ T cells, CD8+ T cells, Regulatory T cells
Key PathwaysTCR signaling, IL-2/JAK-STAT, IFN-gamma production, TNF-alpha, TGF-beta/Treg axis
Associated DiseasesAlzheimer's disease (neuroinflammation), Multiple sclerosis (autoimmune), Parkinson's disease (alpha-syn-reactive T cells), HIV/AIDS, Autoimmune encephalitis
Related GenesPD-L1, CD8, TCR, CD33, Inflammatory Factors, CD4
Linked Hypotheses98 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

Atypical Parkinsonism

disease · 6876 words

neuroinflammation

mechanism · 5462 words

Pathway Diagram

graph TD
    T_cells["T cells"] -->|"regulates"| Inflammatory_Factors["Inflammatory Factors"]
    style Inflammatory_Factors fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    T_cells["T cells"] -->|"infiltrates"| ALS["ALS"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    T_cells["T cells"] -->|"regulates"| Amyloid_plaque_accumulation["Amyloid plaque accumulation"]
    style Amyloid_plaque_accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    T_cells["T cells"] -->|"activates"| neuroinflammation["neuroinflammation"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    T_cells["T cells"] -->|"infiltrates"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    style amyotrophic_lateral_sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    T_cells["T cells"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
    style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    T_cells["T cells"] -.->|"inhibits"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    PD_L1["PD-L1"] -.->|"inhibits"| T_cells["T cells"]
    style PD_L1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CD8["CD8"] -->|"associated"| T_cells["T cells"]
    style CD8 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CD4["CD4"] -->|"associated"| T_cells["T cells"]
    style CD4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TCR["TCR"] -->|"expressed in"| T_cells["T cells"]
    style TCR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"expressed in"| T_cells["T cells"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style T_cells fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (138)

TargetRelationTypeStr
Inflammatory Factorsupregulatesprotein0.80
ALSinfiltratesdisease0.80
Amyloid plaque accumulationregulatesprocess0.70
neuroinflammationactivatesdisease0.70
amyotrophic lateral sclerosisinfiltratesdisease0.70

Incoming (715)

SourceRelationTypeStr
PD-L1inhibitsprotein0.90
CD8associated_withgene0.90
CD4associated_withgene0.90
TCRexpressed_ingene0.90
RNAexpressed_ingene0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Can metabolic interventions truly reverse established cellular senescence or onl

cell biology | 2026-04-08 | 0 hypotheses

How do host cell factors influence the conformation and propagation properties o

neurodegeneration | 2026-04-08 | 0 hypotheses

What molecular mechanisms drive microglial senescence and the transition to dyst

neurodegeneration | 2026-04-06 | 0 hypotheses

How can senescent microglia be molecularly distinguished from beneficial activat

neurodegeneration | 2026-04-06 | 0 hypotheses

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found