gene 2,466 words KG: NMNAT1 2026-03-27
kind:genesection:genesstate:published
Contents

NMNAT1 Gene

🧬 Gene Info
Gene SymbolNMNAT1
Full NameNicotinamide Mononucleotide Adenylyltransferase 1
Chromosome1p36.22
Protein TypeEnzyme
Functionencodes a crucial enzyme in NAD+ biosynthesis that catalyzes the final step in the NAD+ salvage pathway: the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NA...
Primary Expressiontissues with high metabolic demand
Subcellular Localizations and tissue expression patterns. While NMNAT1 is primarily studied in the context of Leber congenital amaurosis (LCA)
Molecular Weight32 kDa
Amino Acids279 aa
Exons13
UniProt ID[Q9PVN7](https://www.uniprot.org/uniprot/Q9PVN7)
Ensembl IDENSG00000160714
OMIM608709
GeneCardsNMNAT1
Human Protein AtlasNMNAT1
Associated Diseasesneurodegeneration
InteractionsRb, NEURON, ALZHEIMER'S DISEASE, CASPASE-3, ALZHEIMER, NAD
KG Connections24 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.39
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

sarm1-programmed-axon-degeneration
mechanism · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: inhibits
nad-augmentation-therapy-early-ad
general · KG edge: inhibits
Neurodegeneration
disease · KG edge: implicated_in
Motor Neuron Disease
redirect · KG edge: inhibits

Knowledge Graph (12 edges)

NMNAT1 inhibits Rb
NMNAT1 inhibits Alzheimer
NMNAT1 inhibits Oxidative Stress
NMNAT1 inhibits Dopaminergic
NMNAT1 inhibits Neuron
NMNAT1 inhibits NEURON
NMNAT1 inhibits ALZHEIMER'S DISEASE
NMNAT1 expressed_in Substantia Nigra
NMNAT1 expressed_in Neuron
NMNAT1 inhibits CASPASE-3