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mechanism 1,124 words KG: SARM1
Contents

sarm1-programmed-axon-degeneration

⚙ Mechanism Info
NameSARM1
Key Genes/ProteinsBDNF, AXON
Related DiseasesDepressive-Like Behavior, Alzheimer's Disease, Memory Impairment
Related PathwaysJnk/Sting/Tbk1 Pathway
Linked Hypotheses1 hypotheses

Knowledge Graph

Related Hypotheses (6)

Netrin-1 Gradient Restoration
Score: 0.33Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47Cryptic Exon Silencing Restoration
Score: 0.46Cross-Seeding Prevention Strategy
Score: 0.45Glycine-Rich Domain Competitive Inhibition
Score: 0.43

Related Analyses (30)

Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: activatesApoptosis Pathway in Neurodegeneration
mechanism · KG edge: activatesPackard Center for ALS Research
institution · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesC4B Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

SARM1 activates DLK
SARM1 activates PUMA
SARM1 activates Ms
SARM1 activates Apoptosis
SARM1 activates Mapk
SARM1 activates GBM
SARM1 therapeutic_target GLIOBLASTOMA
SARM1 therapeutic_target CANCER
SARM1 activates Tumor
SARM1 therapeutic_target Glioma
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