Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Dopaminergic: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | Dopaminergic |
| Definition | The CT1-DAP001 trial is a pioneering Phase 1/2 clinical study evaluating the safety and efficacy of human induced pluripotent stem cell (iPSC)-derived dopaminergic progenitor cells for the treatment of Parkinson's disease. Sponsored by the University of California, San Diego, this trial represents a |
| Key Markers | HFE, JUN, MITOCHONDRIA, TFR1, PARKINSON, NEURON, GCASE, PLIN2 |
| Key Pathways | Cell Cycle, Epigenetic, Autophagy, Inflammasome, Adaptive Immunity |
| Associated Diseases | Ischemia, Als, Aging, Neurodegeneration, Parkinson, Senescence |
| Linked Hypotheses | 86 hypotheses |
Knowledge base pages for this entity
graph TD
Dopaminergic["Dopaminergic"] -->|"expressed in"| Substantia_Nigra["Substantia Nigra"]
style Substantia_Nigra fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Dopaminergic["Dopaminergic"] -->|"expressed in"| Striatum["Striatum"]
style Striatum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Dopaminergic["Dopaminergic"] -->|"expressed in"| Thalamus["Thalamus"]
style Thalamus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Dopaminergic["Dopaminergic"] -->|"expressed in"| Hypothalamus["Hypothalamus"]
style Hypothalamus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Dopaminergic["Dopaminergic"] -->|"expressed in"| Cerebellum["Cerebellum"]
style Cerebellum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Dopaminergic["Dopaminergic"] -->|"expressed in"| Prefrontal_Cortex["Prefrontal Cortex"]
style Prefrontal_Cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Dopaminergic["Dopaminergic"] -->|"expressed in"| Cortex["Cortex"]
style Cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
HFE["HFE"] -->|"regulates"| Dopaminergic["Dopaminergic"]
style HFE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
JUN["JUN"] -->|"regulates"| Dopaminergic["Dopaminergic"]
style JUN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
MITOCHONDRIA["MITOCHONDRIA"] -->|"associated"| Dopaminergic["Dopaminergic"]
style MITOCHONDRIA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
TFR1["TFR1"] -->|"regulates"| Dopaminergic["Dopaminergic"]
style TFR1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
PARKINSON["PARKINSON"] -->|"associated"| Dopaminergic["Dopaminergic"]
style PARKINSON fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style Dopaminergic fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Substantia Nigra | expressed_in | brain_region | 0.50 |
| Striatum | expressed_in | brain_region | 0.50 |
| Thalamus | expressed_in | brain_region | 0.50 |
| Hypothalamus | expressed_in | brain_region | 0.50 |
| Cerebellum | expressed_in | brain_region | 0.50 |
| Prefrontal Cortex | expressed_in | brain_region | 0.50 |
| Cortex | expressed_in | brain_region | 0.50 |
| Brainstem | expressed_in | brain_region | 0.50 |
| Putamen | expressed_in | brain_region | 0.50 |
| Hippocampus | expressed_in | brain_region | 0.50 |
| Gray Matter | expressed_in | brain_region | 0.50 |
| Ventral Tegmental Area | expressed_in | brain_region | 0.50 |
| Spinal Cord | expressed_in | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HFE | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| TFR1 | regulates | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| NEURON | causes | gene | 0.60 |
| GCASE | causes | gene | 0.60 |
| PLIN2 | causes | gene | 0.60 |
| GBA | causes | gene | 0.60 |
| AGING | causes | gene | 0.60 |
| SLC6A3 | regulates | gene | 0.60 |
| HUNTINGTON | regulates | gene | 0.60 |
| TUBB | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| TUBB3 | regulates | gene | 0.60 |
| TUBB4B | regulates | gene | 0.60 |
| NDUFA9 | regulates | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| SYNAPSE | regulates | gene | 0.60 |
| NEURON | inhibits | gene | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| RGS6 | associated_with | gene | 0.60 |
| GCH1 | activates | gene | 0.60 |
| SLC6A3 | activates | gene | 0.60 |
| NUCKS1 | activates | gene | 0.60 |
| SLC6A2 | activates | gene | 0.60 |
| GPNMB | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| CYP2D6 | activates | gene | 0.60 |
| SLC6A4 | activates | gene | 0.60 |
| ABCB1 | activates | gene | 0.60 |
| SNCA | activates | gene | 0.60 |
| DRD2 | activates | gene | 0.60 |
| PARKINSON | protects_against | gene | 0.60 |
| LRRK2 | activates | gene | 0.60 |
| PSAP | interacts_with | gene | 0.60 |
| NEURON | interacts_with | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| GPR37 | activates | gene | 0.60 |
| GFP | associated_with | gene | 0.60 |
| ACTB | associated_with | gene | 0.60 |
| ATG7 | associated_with | gene | 0.60 |
| SQSTM1 | inhibits | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| IL1B | inhibits | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| NLRP3 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio | 0.494 | neuroscience | Circuit-level neural dynamics in neurode |
| Correcting Gut Microbial Dopamine Imbalance to Support Syste | 0.412 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987] | Al Saeedy DY, Hawkins E, Dozmorov MG, Tr | J Mol Neurosci | 2026 | 0 |
| A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128] | ["Bolsewig K", "Bellomo G", "Hok-A-Hin Y | Nature medicine | 2026 | 0 |
| Plasma pTau 217/β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertain [PMID:41562409] | Benina N, Buitrago L, De Simone FI, Radw | Brain | 2026 | 0 |
| Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by [PMID:39881147] | ["Bolsewig K", "Willemse E", "S\u00e1nch | Nature communications | 2025 | 0 |
| Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral ph [PMID:37573958] | ["Montillot C", "Skutunova E", "Ayushma" | Neurobiology of disease | 2023 | 0 |
| Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neu [PMID:36692274] | ["Motta C", "Assogna M", "Bonomi C", "Di | European journal of neurology | 2023 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] | Liu J, Xie J | International journal of envir | 2020 | 0 |
| Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] | Karas M, Marinsek N, Goldhahn J, Foschin | Digital biomarkers | 2020 | 0 |
| DOPA Decarboxylase Modulates Tau Toxicity. [PMID:28751068] | ["Kow R", "Sikkema C", "Wheeler J", "Wil | Biological psychiatry | 2018 | 0 |