concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CASPASE

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (207)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
Parkinson	inhibits	disease	0.60
Pyroptosis	activates	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Cancer	activates	disease	0.60
Retinopathy	associated_with	disease	0.60
Cardiomyopathy	associated_with	disease	0.60
Huntington	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Stroke	inhibits	disease	0.60
Hypertension	inhibits	disease	0.60
Depression	interacts_with	disease	0.60
Lymphoma	phosphorylates	disease	0.60
Multiple Sclerosis	activates	disease	0.60
Traumatic Brain Injury	inhibits	disease	0.60
Necroptosis	protects_against	disease	0.60
Parkinson	protects_against	disease	0.60
Als	protects_against	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Anxiety	expressed_in	disease	0.60
Depression	expressed_in	disease	0.60
Pyroptosis	causes	disease	0.60
Stroke	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Als	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Als	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Cancer	expressed_in	disease	0.60
Dementia	causes	disease	0.60
Neurodegeneration	causes	disease	0.60
Diabetes	inhibits	disease	0.60
Cardiomyopathy	inhibits	disease	0.60
Alzheimer	regulates	disease	0.60
Lymphoma	expressed_in	disease	0.60
Als	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Alzheimer	associated_with	disease	0.60
Parkinson	activates	disease	0.60
Dementia	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Als	activates	disease	0.60
Alzheimer	causes	disease	0.60
Dementia	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Stroke	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60

Incoming (602)

Source	Relation	Type	Str
UBIQUITIN	inhibits	gene	0.60
CX43	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
VEGF	associated_with	gene	0.60
AKT	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
HO-1	associated_with	gene	0.60
TLR	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CREB	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
GAIN	causes	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NRF2	degrades	gene	0.60
STROKE	inhibits	gene	0.60
KEAP1	degrades	gene	0.60
HO-1	degrades	gene	0.60
NLRP3	degrades	gene	0.60
NQO1	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ASC	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
IL-4	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
IL-1	therapeutic_target	gene	0.60
NRF2	activates	gene	0.60
GPX4	activates	gene	0.60
ATG5	activates	gene	0.60
LC3	activates	gene	0.60
XCT	activates	gene	0.60
COX2	activates	gene	0.60
NCOA4	activates	gene	0.60
HO-1	activates	gene	0.60
AIM2	regulates	gene	0.60
MLKL	regulates	gene	0.60
RIPK3	activates	gene	0.60
ZBP1	regulates	gene	0.60
GSDMD	regulates	gene	0.60
TBK1	activates	gene	0.60
DNA	activates	gene	0.60
GASDERMIN	regulates	gene	0.60
IRF3	activates	gene	0.60
AKT	inhibits	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Caspase-2/3-mediated D421 truncation generates disease-speci	0.455	neurodegeneration	Which specific post-translational modifi
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea
Caspase-3 Cleavage of Tau Creates PS-Targeting Specificity	0.000	-	Does tau aggregation specifically cause

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE in their description or question text

No additional research found