concept

CASPASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

809Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CASPASE

Pathway Diagram

graph TD
    CASPASE["CASPASE"]
    style CASPASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CASPASE -->|"activates"| PANoptosis["PANoptosis"]
    CASPASE -->|"cleaves"| GSDME([GSDME])
    CASPASE -->|"activates"| neurodegeneration["neurodegeneration"]
    CASPASE -->|"activates"| IL1B([IL1B])
    CASPASE -->|"regulates"| Fibrosis["Fibrosis"]
    CASPASE -->|"interacts"| Cancer["Cancer"]
    CASPASE -->|"interacts"| Als["Als"]
    CASPASE -.->|"inhibits"| Aging["Aging"]
    RIPK1([RIPK1]) -->|"interacts"| CASPASE
    PPARG([PPARG]) -->|"interacts"| CASPASE
    WNT([WNT]) -->|"regulates"| CASPASE
    TFEB([TFEB]) -->|"interacts"| CASPASE
    CFTR([CFTR]) -->|"regulates"| CASPASE
    RICTOR([RICTOR]) -->|"interacts"| CASPASE
    ROS([ROS]) -->|"regulates"| CASPASE
    GRB2([GRB2]) -->|"interacts"| CASPASE
    HSP70([HSP70]) -->|"interacts"| CASPASE
    STAT3([STAT3]) -->|"interacts"| CASPASE

Outgoing (207)

Target	Relation	Type	Str
PANoptosis	activates	process	0.92
neurodegeneration	activates	process	0.70
Parkinson	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Als	protects_against	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Anxiety	expressed_in	disease	0.60
Depression	expressed_in	disease	0.60
Aging	regulates	disease	0.60
Depression	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Multiple Sclerosis	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Spinal Cord Injury	regulates	disease	0.60
Huntington	regulates	disease	0.60
Diabetes	therapeutic_target	disease	0.60
Aging	therapeutic_target	disease	0.60
Retinopathy	therapeutic_target	disease	0.60
Pyroptosis	causes	disease	0.60
Aging	associated_with	disease	0.60
Pyroptosis	activates	disease	0.60
Cancer	activates	disease	0.60
Retinopathy	associated_with	disease	0.60
Cardiomyopathy	associated_with	disease	0.60
Huntington	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Dementia	causes	disease	0.60
Neurodegeneration	causes	disease	0.60
Als	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Dementia	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Alzheimer	causes	disease	0.60
Cancer	therapeutic_target	disease	0.60
Necroptosis	protects_against	disease	0.60
Parkinson	protects_against	disease	0.60
IL1B	activates	protein	0.60
Cancer	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Dementia	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Stroke	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Diabetes	inhibits	disease	0.60
Cardiomyopathy	inhibits	disease	0.60

Incoming (602)

Source	Relation	Type	Str
VIM	regulates	gene	0.60
WT1	regulates	gene	0.60
LAMP1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ATG14	associated_with	gene	0.60
VIMENTIN	regulates	gene	0.60
HDAC6	regulates	gene	0.60
TUBULIN	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
TJP1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
H2AX	associated_with	gene	0.60
RAC1	regulates	gene	0.60
BECN1	associated_with	gene	0.60
CPT1A	inhibits	gene	0.60
ALOX15	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
PPAR	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
FASN	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
ROS	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
IL6	inhibits	gene	0.60
GAPDH	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
MICROGLIA	inhibits	gene	0.60
GFAP	associated_with	gene	0.60
IL1B	inhibits	gene	0.60
GFP	associated_with	gene	0.60
PARKINSON	inhibits	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
NLRP3	inhibits	gene	0.60
SNCA	inhibits	gene	0.60
AIM2	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
NLR	associated_with	gene	0.60
ATP	associated_with	gene	0.60
IL18	associated_with	gene	0.60
GSDME	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Caspase-2/3-mediated D421 truncation generates disease-speci	0.455	neurodegeneration	Which specific post-translational modifi
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea
Caspase-3 Cleavage of Tau Creates PS-Targeting Specificity	0.000	-	Does tau aggregation specifically cause

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE in their description or question text

No additional research found