gene 1,127 words KG: RAB23
Contents

RAB23 Gene

🧬 Gene Info
Gene SymbolRAB23
Full NameRAB23, Member RAS Oncogene Family
Chromosome6p11.2
Functionencodes a member of the Rab GTPase family, essential regulators of intracellular membrane trafficking.
Primary Expressionvarious brain regions:
Subcellular Localization- **Endocytic vesicles**: Early and late endosomes
Gene TypeProtein coding
UniProt IDQ9ULC5
NCBI Gene ID51684
Ensembl IDENSG00000102710
OMIM607039
GeneCardsRAB23
Human Protein AtlasRAB23
GTP bindingRAB23 binds GTP with high affinity, adopting its active conformation
GTP hydrolysisIntrinsic GTPase activity hydrolyzes GTP to GDP, switching to the inactive state
Associated DiseasesAtherosclerosis
KG Connections8 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Autophagosome Maturation Checkpoint Control
Score: 0.71
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
cdkn2a
gene · KG edge: associated_with
GLS - Glutaminase
gene · KG edge: associated_with
SGCE — Sarcoglycan Epsilon
gene · KG edge: biomarker_for
SLC31A2 — Solute Carrier Family 3 Member 1A2 (SLC31A2)
gene · KG edge: associated_with

Knowledge Graph (8 edges)

SGCE biomarker_for RAB23
NLRP3 associated_with RAB23
SLC31A2 associated_with RAB23
RAB23 associated_with CDKN2A
RAB23 associated_with GLS
RAB23 biomarker_for Als
RAB23 associated_with Atherosclerosis
RAB23 associated_with Actin

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