gene 1,625 words KG: CDKN2A
Contents

CDKN2A Gene

🧬 Gene Info
Gene SymbolCDKN2A
Chromosome9p21.3
Functionis a 156-amino acid protein composed of ankyrin repeat domains that adopt a highly twisted, left-handed helix structure[@li2019].
Molecular Weight16 kDa
Amino Acids156 aa
PathwaysGlycolysis, Tgf-Β
UniProt IDP42771
NCBI Gene ID1029
Ensembl IDENSG00000147883
GeneCardsCDKN2A
Human Protein AtlasCDKN2A
p12^INK4a^Alternatively spliced variant with truncated N-terminus
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsTLR4, TNC, NTRK2, PAK1, KCNK2, CD44
SciDEX HypothesesSenescence-Tau Decoupling Therapy
KG Connections467 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.68
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A
gene · KG edge: associated_with
CDK4 Gene
gene · KG edge: inhibits
CD19 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CDKN2A provides_data_for ds-83b31ef18d49
CDKN2A inhibits cell cycle progression
CDKN2A therapeutic_target EZH2
CDKN2A therapeutic_target NSD3
CDKN2A associated_with GBM
CDKN2A expressed_in PRKCB
CDKN2A expressed_in CLU
CDKN2A expressed_in BECN1
CDKN2A expressed_in CLUSTERIN
CDKN2A regulates TP53