| Gene Symbol | RPS27 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Amino Acids | 84 aa |
| Ensembl ID | ENSG00000177951 |
| GeneCards | RPS27 |
| Human Protein Atlas | RPS27 |
| 40S subunit assembly | Critical for proper ribosome biogenesis |
| mRNA binding | Facilitates mRNA binding to the small ribosomal subunit |
| Translation initiation | Part of the eIF2/EIF2B complex that initiates translation |
| p53 activation | The RPS27-MDM2-p53 axis is critical for tumor suppression and cellular stress response |
| Diamond-Blackfan Anemia (DBA) | RPS19 and RPS24 mutations cause ribosomal stress |
| 5q- syndrome | Deletion of ribosomal protein genes causes bone marrow failure |
| Neurodevelopmental disorders | Mutations in ribosomal proteins cause intellectual disability |
| Ribosomal RNA (rRNA) processing defects | Observed in sporadic ALS |
| Ribosomal protein alterations | Changes in RPS6 and RPS10 in ALS motor neurons |
| Associated Diseases | neurodegeneration |
| Interactions | RPL38, RPS28, RPL35, TARDBP, RPS10, RPS16 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |