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gene 2,779 words KG: SCA7
Contents

SCA7 Gene

🧬 Gene Info
Gene SymbolSCA7
Full NameATXN7 (Ataxin-7)
Chromosome3p12
Protein TypeTransferase
Functionis a 892-amino acid protein with several distinct functional domains
Amino Acids892 aa
Exons13
UniProt ID[Q9UQ50](https://www.uniprot.org/uniprotkb/Q9UQ50/entry)
GeneCardsSCA7
Human Protein AtlasSCA7
Histone acetylationThrough the GCN5 acetyltransferase activity
Histone deubiquitinationThrough the USP22 deubiquitinase activity
Transcriptional activationBy bridging transcription factors with the basal transcriptional machinery
Associated DiseasesAtaxia
InteractionsATG12
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.89Transcriptional Autophagy-Lysosome Coupling
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77PARP1 Inhibition Therapy
Score: 0.74Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Autophagosome Maturation Checkpoint Control
Score: 0.71Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69Sphingolipid Metabolism Reprogramming
Score: 0.62Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61VCP-Mediated Autophagy Enhancement
Score: 0.59

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (12 edges)

SCA3 regulates SCA7
SCA7 regulates SPG7
SCA3 co_expressed_with SCA7
SCA7 co_expressed_with SPG7
RAN associated_with SCA7
SCA3 associated_with SCA7
LAMP2 biomarker_for SCA7
LC3 biomarker_for SCA7
ATG12 interacts_with SCA7
SCA7 regulates neurodegeneration

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