gene 1,528 words KG: SCA3
Contents

SCA3 — ATXN3 (Ataxin-3)

🧬 Gene Info
Gene SymbolSCA3
Full NameATXN3 (Ataxin-3)
Chromosome14q32.1.
Functionis a 361-amino acid protein encoded by the ATXN3 gene located on chromosome 14q32.
Amino Acids361 aa
UniProt ID[Q9UHD8](https://www.uniprot.org/uniprotkb/Q9UHD8/entry)
GeneCardsSCA3
Human Protein AtlasSCA3
Associated DiseasesAtaxia, Huntington, Huntington's disease, Ms, Neurodegeneration, Spinocerebellar Ataxia
InteractionsUSP7, VCP, ATXN3, G3BP1, CACNA1A, ATM
KG Connections123 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (14)

Packard Center for ALS Research
institution · KG edge: biomarker_for
HSPA1A Gene
gene · KG edge: regulates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: regulates
DNAJB1 Gene
gene · KG edge: regulates
CYCS
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SCA3 regulates DNAJB1
SCA3 associated_with ATG12
SCA3 associated_with SQSTM1
SCA3 associated_with BECN1
SCA3 associated_with UBC
SCA3 associated_with ATG7
SCA3 associated_with P62
SCA3 associated_with SOD1
SCA3 associated_with CYCS
SCA3 implicated_in RAB7