gene 1,304 words KG: STAT5B 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammationtopic:immune-responsestate:published
Contents

STAT5B Gene

🧬 Gene Info
Gene SymbolSTAT5B
Full NameSignal Transducer and Activator of Transcription 5B
Chromosome12p13.31
Functionencodes a protein of approximately 787 amino acids.
Amino Acids787 aa
Exons19
PathwaysJAK-STAT, NF-κB
UniProt ID[P51692](https://www.uniprot.org/uniprot/P51692)
Ensembl IDENSG00000173728
GeneCardsSTAT5B
Human Protein AtlasSTAT5B
STAT-binding sitesAutoregulation by STAT5 signaling
NF-κB elementsIntegration with inflammatory signals
Cell-type specific enhancersDirect immune and neuronal expression
TATA boxInitiator-driven transcription
Associated DiseasesCancer
KG Connections25 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

LAG3 Protein (CD223)
protein · KG edge: associated_with
Hedgehog Signaling in Neurodegeneration
mechanism · KG edge: associated_with
RPL17 — Ribosomal Protein L17
gene · KG edge: binds
MS4A4A Gene — Membrane-Spanning 4-Domains A4A
gene · KG edge: associated_with
FOXP3 (Forkhead Box P3)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

STAT5B associated_with Il-6
STAT5B associated_with Stat3
STAT5B associated_with PFKFB3
STAT5B associated_with PD-L1
STAT5B associated_with Cancer
STAT5B associated_with Nf-Κb
STAT5B associated_with Pi3K/Akt
STAT5B associated_with Notch
STAT5B associated_with Mtor
STAT5B associated_with T Cell