gene 3,294 words KG: MS4A4A 2026-03-25
kind:genesection:genesstate:published
Contents

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

🧬 Gene Info
Gene SymbolMS4A4A
Full NameMembrane-Spanning 4-Domains A4A
Chromosome11q12.2
Functionencodes a membrane protein expressed primarily in immune cells, particularly microglia and other myeloid cells.
Primary Expressionimmune cells, particularly microglia and other myeloid cells
Molecular Weight~22 kDa
Amino Acids199 aa
Exons6
UniProt IDQ9H3Y1
NCBI Gene ID246213
Ensembl IDENSG00000166926
OMIM614508
GeneCardsMS4A4A
Human Protein AtlasMS4A4A
Protein Length199 amino acids
Associated DiseasesAlzheimer's disease, Cancer
InteractionsMS4A6A, MS4A6E, TREM2, APOE, CLU, CR1
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Membrane Cholesterol Gradient Modulators
Score: 0.52

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.46

See Also (10)

LAG3 Protein (CD223)
protein · KG edge: associated_with
Hedgehog Signaling in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
FOXP3 (Forkhead Box P3)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MS4A4A associated_with CCR8
MS4A4A associated_with LAG3
MS4A4A associated_with TGFB1
MS4A4A associated_with FOXP3
MS4A4A associated_with CD163
MS4A4A associated_with STAT5B
MS4A4A associated_with Il-6
MS4A4A associated_with Stat3
MS4A4A interacts_with MS4A6A
MS4A4A inhibits Microglia Phagocytosis