| Gene Symbol | LAG3 |
| Aliases | CD223 |
| Protein Type | Receptor |
| Function | LAG3 is primarily expressed on activated T cells, regulatory T cells (Tregs), natural killer cells, and to a lesser extent on B cells and dendritic cells. |
| Molecular Weight | 57 kDa |
| Pathways | Alpha-Synuclein Transmission |
| UniProt ID | [P18627](https://www.uniprot.org/uniprotkb/P18627) |
| GeneCards | LAG3 |
| Human Protein Atlas | LAG3 |
| Approach | Mechanism |
| Blocking antibodies | Prevent fibril binding/uptake |
| Soluble LAG3 | Decoy receptor for fibrils |
| Small molecule inhibitors | Block LAG3-fibril interaction |
| MHC Class II | Physiological |
| Alpha-synuclein fibrils | Pathological |
| Associated Diseases | Cancer, MICROGLIAL ACTIVATION, Parkinson's Disease |
| Interactions | APLP1, FOXP3, PI3K, RICTOR, MYC, RAGE |
| KG Connections | 121 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |