| Gene Symbol | TPPP |
| Function | TPPP encodes a 219 amino acid intrinsically disordered protein with no conventional secondary structure domains. |
| Primary Expression | oligodendrocytes where it stabilizes microtubules and promotes tubulin acetylation |
| Amino Acids | 219 aa |
| Pathways | Autophagy, Proteasome |
| Ensembl ID | ENSG00000171368 |
| GeneCards | TPPP |
| Human Protein Atlas | TPPP |
| Glial cytoplasmic inclusions (GCIs) | TPPP co-localizes with aggregated alpha-synuclein in virtually all GCIs, the pathological hallmark of MSA |
| Seeding and templating | TPPP directly binds alpha-synuclein and promotes its aggregation into a GCI-specific amyloid strain distinct from Lewy body strains |
| Relocation | In MSA, TPPP relocates from its normal perinuclear/process distribution to the inclusion body, depleting it from microtubules and causing secondary demyelination |
| Temporal sequence | Evidence suggests TPPP accumulation precedes alpha-synuclein aggregation in GCIs — TPPP may create the initial seed |
| Strain specificity | The TPPP-alpha-synuclein complex generates a prion-like strain with unique structural properties, potentially explaining MSA's aggressive clinical course compared to PD |
| Associated Diseases | neurodegeneration |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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