| Gene Symbol | ent-gene-3d51813d |
| Primary Expression | Low in homeostatic microglia; massively upregulated (10-50x) in DAM/lipid-laden microglia in AD, PD, GBA-PD, and Gaucher disease[@kerenshaul2017] |
| Subcellular Localization | Cell surface of activated/dysfunctional microglia; shed ectodomain detectable in CSF |
| Primary Target | GPNMB (extracellular domain) on lipid-laden microglia |
| Target Type | Antibody-drug conjugate (ADC) for LLM depletion, or anti-GPNMB agonist antibody to restore phagocytic function |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |