idea 2,957 words KG: ent-gene-a90f5952 2026-03-24
kind:ideakind:therapy-ideasection:ideasstate:published
Contents

VPS35 Retromer Stabilizer for Lysosomal Rescue

🔬 Protein Info
Gene Symbolent-gene-a90f5952
Primary ExpressionUbiquitous; critical in neurons due to extreme endosomal trafficking demand (synaptic vesicle recycling, receptor sorting)
Subcellular LocalizationEndosomal membrane; cycles between early endosomes, recycling endosomes, and trans-Golgi network
Primary TargetVPS35-VPS29 interface of the retromer cargo-selective complex
Target TypePharmacological chaperone / protein-protein interaction stabilizer
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55

Related Analyses (9)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (4)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-a90f5952 data_in benchmark_ot_ad_answer_key:VPS35
benchmark_ot_ad_answer_key:VPS35 data_in ent-gene-a90f5952