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mechanism 1,593 words KG: extracellular matrix 2026-03-31
kind:mechanismsection:mechanismsdisease:pspdisease:cbddisease:agddisease:ggtdisease:ftdp-17topic:4r-tauopathiestopic:extracellular-matrixtopic:perineuronal-nets
Contents

Extracellular Matrix and Perineuronal Nets in 4R-Tauopathies

⚙ Mechanism Info
NameExtracellular Matrix and Perineuronal Nets in 4R-Tauopathies
SummaryCross-disease mechanism analysis of ECM remodeling and perineuronal net dysregulation in PSP, CBD, AGD, GGT, and FTDP-17
Key Genes/ProteinsHSPG2, JUN, MMP9, HAPLN4
Related Diseasesfibrosis
Linked Hypotheses2 hypotheses

Knowledge Graph

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Score: 0.41

Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
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neurodegeneration · archived

Related Experiments (2)

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clinical · proposed · Score: 0.40

See Also (15)

Angiogenesis Pathway
mechanism · KG edge: activatesAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_withPackard Center for ALS Research
institution · KG edge: activatesAlzheimer Indonesia
institution · KG edge: activatesAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (9 edges)

extracellular matrix contributes_to fibrosis
extracellular matrix regulates synaptic remodeling
extracellular matrix regulates C1q deposition
extracellular matrix regulates C3 deposition
HAPLN4 participates_in extracellular matrix
HSPG2 involved_in extracellular matrix
programmed cell death associated_with extracellular matrix
JUN inhibits extracellular matrix
MMP9 remodels extracellular matrix
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