gene 1,014 words KG: HAPLN4 2026-03-26
kind:genesection:genestopic:alzheimerstopic:schizophreniatopic:epilepsy
Contents

HAPLN4 Gene (Hyaluronan and Proteoglycan Link Protein 4)

🧬 Gene Info
Gene SymbolHAPLN4
Functionencodes a member of the hyaluronan and proteoglycan link protein (HAPLN) family.
Amino Acids402 aa
PathwaysMAPK pathway
Ensembl IDENSG00000166920
GeneCardsHAPLN4
Human Protein AtlasHAPLN4
Associated DiseasesAlzheimer's disease, Schizophrenia, Epilepsy
KG Connections8 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (8)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Extracellular Matrix and Perineuronal Nets in 4R-Tauopa
mechanism · KG edge: participates_in
Neurodegeneration
disease · KG edge: implicated_in
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses

Knowledge Graph (8 edges)

HAPLN4 regulates GABAergic synapses
HAPLN4 component_of perineuronal nets
HAPLN4 participates_in extracellular matrix
HAPLN4 interacts_with MAPK pathway
HAPLN4 expressed_in Purkinje cells
HAPLN4 expressed_in Deep cerebellar nuclei neurons
HAPLN4 regulates Fast-signaling synapses
HAPLN4 participates_in Extracellular matrix