concept

HSPG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

435Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

HSPG2 is a concept in neurodegeneration research. Key relationships include: interacts with, implicated in, regulates. Associated with AD, ADH, ALI. Connected to 133 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HSPG2
Key Genes/Proteins	AMYLOID-BETA, APRIL, TAU
Related Diseases	Radioresistance, Prostate Cancer
Related Pathways	extracellular matrix, Cell Adhesion-Mediated Signaling

🔮 Predicted Structure: HSPG2 — AlphaFold P98160 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HSPG2["HSPG2"]
    HSPG2 -->|"target for"| Als["Als"]
    HSPG2 -->|"regulates"| Fibrosis["Fibrosis"]
    HSPG2 -->|"regulates"| Cancer["Cancer"]
    HSPG2 -->|"regulates"| Ms["Ms"]
    HSPG2 -->|"inhibits"| Tumor["Tumor"]
    HSPG2 -->|"interacts"| Cardiovascular["Cardiovascular"]
    HSPG2 -->|"interacts"| Inflammation["Inflammation"]
    HSPG2 -->|"regulates"| Atherosclerosis["Atherosclerosis"]
    HSPG2 -->|"interacts"| Stroke["Stroke"]
    h_c35493aa["h-c35493aa"] -->|"targets"| HSPG2
    NCSTN["NCSTN"] -->|"interacts"| HSPG2
    FAS["FAS"] -->|"interacts"| HSPG2
    TNF["TNF"] -->|"interacts"| HSPG2
    LMNA["LMNA"] -->|"interacts"| HSPG2
    APH1B["APH1B"] -->|"interacts"| HSPG2
    APOE["APOE"] -->|"interacts"| HSPG2
    IL6["IL6"] -->|"interacts"| HSPG2
    SREBF1["SREBF1"] -->|"interacts"| HSPG2
    PSEN2["PSEN2"] -->|"interacts"| HSPG2

Outgoing (284)

Target	Relation	Type	Str
Radioresistance	regulates	phenotype	0.95
HEPARAN_SULFATE	core_protein_of	glycan	0.95
SENILE_PLAQUE	component_of	pathology	0.90
extracellular matrix	involved_in	pathway	0.90
AMYLOID-BETA	co-localizes_with	protein	0.90
TAU	promotes_aggregation_of	protein	0.85
CEREBRAL_AMYLOID_ANGIOPATHY	component_of	pathology	0.85
Prostate Cancer	associated_with	disease	0.85
Prostate Cancer	implicated_in	disease	0.85
Cell Adhesion-Mediated Signaling	involved_in	pathway	0.82
PRION-LIKE_SPREADING	mediates	process	0.80
Prostate Cancer	regulates	disease	0.80
ALPHA-SYNUCLEIN	promotes_aggregation_of	protein	0.80
oxidative stress response	participates_in	pathway	0.80
CROSS_SEEDING	platform_for	process	0.75
TREM2	co-regulates_clearance_with	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
Myasthenia Gravis	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Fibrosis	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Atherosclerosis	regulates	disease	0.65
Stroke	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Hypertension	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Diabetes	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
ALS	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	regulates	disease	0.65

Incoming (151)

Source	Relation	Type	Str
Hsv-1	binds	entity	0.95
APRIL	binds_to	protein	0.90
h-c35493aa	targets_gene	hypothesis	0.90
h-54b9e0f5	targets_gene	hypothesis	0.90
h-c35493aa	targets	hypothesis	0.80
Herpes simplex virus 1	binds_to	virus	0.80
NCSTN	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
DAG1	regulates	gene	0.60
EIF2AK2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
CD44	biomarker_for	gene	0.60
IGF1	biomarker_for	gene	0.60
EGF	biomarker_for	gene	0.60
KDR	biomarker_for	gene	0.60
FGF9	biomarker_for	gene	0.60
BAD	regulates	gene	0.60
APP	interacts_with	gene	0.60
IGF1R	regulates	gene	0.60
DYNEIN	interacts_with	gene	0.60
BAD	activates	entity	0.60
DAG1	activates	entity	0.60
SORL1	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
IL10	associated_with	gene	0.60
PLAU	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ACE	associated_with	gene	0.60
TXNRD1	expressed_in	gene	0.60
DDX3X	expressed_in	gene	0.60
SHH	expressed_in	gene	0.60
GLI1	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Glycosaminoglycan Template Disruption Approach	0.464	neurodegeneration	Protein aggregation cross-seeding across
Glial Glycocalyx Remodeling Therapy	0.415	neurodegeneration	4R-tau strain-specific spreading pattern

Mentioning Analyses (2)

Scientific analyses that reference this entity

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.488

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic sc [PMID:38448448]	Yang ZR, Suo H, Fan JW, Lv N, Du K, Ma T	Nat Commun	2024	1
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p [PMID:39149513]	Samaržija I, Lukiyanchuk V, Lončarić M,	Front Cell Dev Biol	2024	1
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. [PMID:34433968]	Tsiantoulas D, Eslami M, Obermayer G, Cl	Nature	2021	1
Interactions between the products of the Herpes simplex genome and Alzheimer's d [PMID:18164103]	Carter CJ	Neurochem Int	2008	1
Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437]	Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L	Biomedical materials (Bristol,	2026	0
Trichomonas vaginalis adhesion protein 65 facilitates human papillomavirus entry [PMID:41199321]	Mei X, Sheng W, Zhang Y, Tian W, Tian X,	Infectious diseases of poverty	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
The interaction of endorepellin and neurexin triggers neuroepithelial autophagy [PMID:38702277]	Lu L, Bai M, Zheng Y, Wang X, Chen Z, Pe	Science bulletin	2024	0
Diverse and multifunctional roles for perlecan (HSPG2) in repair of the interver [PMID:39081381]	Melrose J, Guilak F	JOR spine	2024	0
Spatial transcriptomics reveal markers of histopathological changes in Duchenne [PMID:37582915]	Heezen LGM, Abdelaal T, van Putten M, Aa	Nature communications	2023	0
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022	0
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021	0
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021	0
Effects of different types of land-use on taxonomic and functional diversity of [PMID:33847890]	["Liu Z", "Li Z", "Castro D", "Tan X", "	Environmental science and poll	2021	0
Combining population genomics and fitness QTLs to identify the genetics of local [PMID:29686078]	Price N, Moyers BT, Lopez L, Lasky JR, M	Proceedings of the National Ac	2018	0
Author Correction: Distinct effects of social motivation on face evaluations in [PMID:30573750]	Safra L, Ioannou C, Amsellem F, Delorme	Scientific reports	2018	0
[Correlation of fibroblast growth factor 23 with  adverse prognosis of chronic k [PMID:29886473]	["Liu H", "Liu H"]	Zhong nan da xue xue bao. Yi x	2018	0
The link between dissociation and both suicide attempts and non-suicidal self-in [PMID:28196773]	["Calati R", "Bensassi I", "Courtet P"]	Psychiatry research	2017	0
Midkine is a serum and urinary biomarker for the detection and prognosis of non- [PMID:27974680]	Xia X, Lu JJ, Zhang SS, Su CH, Luo HH	Oncotarget	2016	0

HSPG2

Understanding Entity Pages

Summary

Wiki Pages (20)

cognitive-reserve-cbs-psp

Granulovacuolar Bodies: Neuronal Defense Mechanism Against Tau Pathology

nct02605785-tau-pet-psp

Tau Proteostasis and Clearance Across 4R-Tauopathies

Davunetide (AL-108) PSP Trial

Computational Models of Tau Propagation in Progressive Supranuclear Palsy

FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear Palsy

oga-inhibition-tau

DTI White Matter Changes in CBS/PSP

section-197-advanced-clinical-trial-design-cbs-psp

Computational Tau Spreading Models in Progressive Supranuclear Palsy

neflamapimod-psp

Protein Aggregation in Neurodegeneration

Protein Aggregation in Neurodegenerative Disease Comparison

Protein Aggregation and Misfolding in Neurodegeneration

Tau-PROTAC Heterobifunctional Degrader for Tauopathy

BIIB080 (MAPTRx) ASO Therapy for PSP

Neurotransmitter Dysfunction in Progressive Supranuclear Palsy

FGF6 Gene

Syde® Digital Endpoints for PSP (NCT07389018)