mechanism 1,753 words KG: ent-gene-694200ea 2026-04-01
kind:section:mechanismsevidence:strongmechanismsection:mechanismsstate:publishedtopic:parkinsons
Contents

GBA Glucocerebrosidase Dysfunction and Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-694200ea
Chromosome1q21
Subcellular LocalizationLysosomal lumen
Molecular weight~60 kDa
Active siteAcidic (optimal pH 5.4)
CofactorNone (glycosyl hydrolase family)
TraffickingMannose-6-phosphate receptor-mediated
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Microbial Inflammasome Priming Prevention
Score: 0.58

Related Analyses (30)

Does TFEB activation directly restore mutant GBA enzyme acti
molecular biology · failed
What is the therapeutic window between GCS inhibition effica
neurodegeneration · failed
GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's D
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Genetic Risk Modifiers in DLB Phenotype
clinical · proposed · Score: 0.40

See Also (15)

Yoga Therapy for Neurodegeneration
therapeutic · Pages share 4 hypotheses
YAP/TEAD Pathway Modulators for Neurodegeneration
therapeutic · Pages share 4 hypotheses
Wnt Signaling Modulators for Neurodegeneration
therapeutic · Pages share 4 hypotheses
vitamin-d-therapy-neurodegeneration
therapeutic · Pages share 4 hypotheses
Vitamin B Complex Therapy for Neurodegeneration
therapeutic · Pages share 4 hypotheses

Knowledge Graph (2 edges)

ent-gene-694200ea data_in benchmark_ot_ad_answer_key:GBA
benchmark_ot_ad_answer_key:GBA data_in ent-gene-694200ea